ArticleAnnals of biomedical engineering2011
MEMS thermal sensors to detect changes in heat transfer in the pre-atherosclerotic regions of fat-fed New Zealand white rabbits.
Article in Annals of biomedical engineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Interventionist videothermometry: a new model of cardiac ischemia evaluation.BMC veterinary research · 2020Article
- Blood flow modulation of vascular dynamics.Current opinion in lipidology · 2015Review
- Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits.Biosensors & bioelectronics · 2014Article
- Potential of thermal imaging as a tool for prediction of cardiovascular disease.Journal of medical physics · 2014Article
- Atrial fibrillation pacing decreases intravascular shear stress in a New Zealand white rabbit model: implications in endothelial function.Biomechanics and modeling in mechanobiology · 2013Article
- Elevated electrochemical impedance in the endoluminal regions with high shear stress: implication for assessing lipid-rich atherosclerotic lesions.Biosensors & bioelectronics · 2013Article
- Flexible microelectrode arrays to interface epicardial electrical signals with intracardial calcium transients in zebrafish hearts.Biomedical microdevices · 2012Article
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6 authors.
Funding
Abstract
Real-time detection of pre-atherosclerotic regions remains an unmet clinical challenge. We previously demonstrated the application of micro-electro-mechanical systems (MEMS) to detect changes in convective heat transfer in terms of sensor output voltages in the zone of flow reversal in an in vitro stenotic model. We hereby demonstrated changes in sensor output voltages in the pre-atherosclerotic regions in the New Zealand White rabbits fed on hypercholesterolemic diet (HD). After 8 weeks, we observed that mean output voltages (V(ave)) were similar in the distal aortic arch, thoracic, and abdominal aortas in the normal standard diet (ND) group, consistent with an absence of atherosclerosis. In HD group, V(ave) increased in the distal aortic arch (HD: V(ave) = 1.05 ± 0.04 V; ND: V(ave) = 0.12 ± 0.01 V, n = 3, p < 0.05) and in the thoracic aortas (HD: V(ave) = 0.72 ± 0.06 V; ND: V(ave) = 0.13 ± 0.024 V, n = 3, p < 0.05), consistent with the histological presence of pre-atherosclerosis. Despite HD diet, V (ave) magnitudes were similar to ND group in the abdominal aortas (HD: V(ave) = 0.14 ± 0.003 V; ND: V(ave) = 0.14 ± 0.004 V, n = 3), corroborating histological absence of pre-atherosclerosis. Hence, MEMS thermal sensors provide a new approach to detect changes in convective heat transfer in the pre-atherosclerotic regions.
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