SynthesisIntensive care medicine2011
Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis.
Synthesis in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 10 of them syntheses that pooled it.
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Who cites it
73 citing papers in PubMed, 10 syntheses or guidelines pooled it, 210 citations in OpenAlex.
- Association of inflammatory biomarkers with overall survival in burn patients: a systematic review and meta-analysis.BMC emergency medicine · 2024Pooled it
- Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis.BMC infectious diseases · 2023Pooled it
- Systematic review and meta-analysis of the diagnostic value of four biomarkers in detecting neonatal sepsis in low- and middle-income countries.BMJ paediatrics open · 2023Pooled it
- Meta-analysis of diagnostic test accuracy studies with multiple thresholds for data integration.Epidemiology and health · 2022Pooled it
- Diagnostic and prognostic predictive values of triggering receptor expressed on myeloid cell-1 expression in neonatal sepsis: A meta-analysis and systematic review.Frontiers in pediatrics · 2022Pooled it
- The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis: a meta-analysis and systematic review.Critical care (London, England) · 2018Pooled it
- Soluble TREM-1 as a predictive factor of neonatal sepsis: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Pooled it
- Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis.BMC infectious diseases · 2017Pooled it
- Meta-analysis of diagnostic accuracy of neutrophil CD64 for neonatal sepsis.Italian journal of pediatrics · 2016Pooled it
- Pooled it
- Pancreatic stone protein as a novel marker for neonatal sepsis.Intensive care medicine · 2013Trial
- Comparing procalcitonin and C-reactive protein levels in very low birth weight infants with sepsis.Pediatric research · 2026Article
- Inter-specialty differences in the management of febrile neonates on prostaglandin E1.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Comparative efficacy of two hemopurification filters for treating intra-abdominal sepsis: A retrospective study.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Point-of-care procalcitonin trends in suspected neonatal late-onset infection: a prospective observational study.Pediatric research · 2025Observational
- Article
- Incorporation of oXiris Bioabsorbent Filter into CRRT in the treatment of severe abdominal infections and analysis of associated risk factors for early off-machine.Frontiers in public health · 2025Article
- Diagnostic value of procalcitonin and hemocyte parameters in neonates with bloodstream infection: Role of activated hemocyte-related genes.Pediatric discovery · 2024Article
- Assessment of inflammatory biomarkers to identify surgical/death necrotizing enterocolitis in preterm infants without pneumoperitoneum.Pediatric surgery international · 2024Article
- Factors Associated with Post-rewarming Procalcitonin Levels in Newborns with Hypoxic Ischemic Encephalopathy.Turkish archives of pediatrics · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the value of serum procalcitonin (PCT) for the differentiation between patients with and without neonatal sepsis.
methodsWe systematically searched PubMed, Scopus, and the Cochrane Library for studies evaluating PCT in neonatal sepsis. PCT had to be measured in neonatal blood samples, at the initial presentation of patients with suspected sepsis, before the administration of antibiotics. We performed a bivariate meta-analysis of sensitivity and specificity, and constructed a hierarchical summary receiver-operating characteristic (HSROC) curve.
resultsOverall, 29 studies eligible for inclusion were identified. We analyzed the 16 studies (involving 1,959 neonates) that evaluated PCT in neonates with culture-proven or clinically diagnosed sepsis in comparison with ill neonates with other conditions. The pooled (95% confidence interval) sensitivity and specificity were 81% (74-87%) and 79% (69-87%), respectively. The area under the HSROC curve (AUC) was 0.87. The diagnostic accuracy of PCT seemed higher for neonates with late-onset sepsis (>72 h of life) than for those with early onset sepsis; the AUC for these analyses was 0.95 and 0.78, respectively. However, fewer data were available for late-onset sepsis. High statistical heterogeneity was observed for all analyses.
conclusionOur findings suggest that serum PCT at presentation has very good diagnostic accuracy (AUC = 0.87) for the diagnosis of neonatal sepsis. However, in view of the marked observed statistical heterogeneity, along with the lack of a uniform definition for neonatal sepsis, the interpretation of these findings should be done with appropriate caution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.