ArticlePLoS pathogens2011
Genital tract sequestration of SIV following acute infection.
Article in PLoS pathogens, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- The importance of semen leukocytes in HIV-1 transmission and the development of prevention strategies.Human vaccines & immunotherapeutics · 2020Review
- HIV and SIV in Body Fluids: From Breast Milk to the Genitourinary Tract.Current immunology reviews · 2019Article
- Seminal Simian Immunodeficiency Virus in Chronically Infected Cynomolgus Macaques Is Dominated by Virus Originating from Multiple Genital Organs.Journal of virology · 2018Article
- TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy.Science translational medicine · 2018Article
- Persistence of SIV in the brain of SIV-infected Chinese rhesus macaques with or without antiretroviral therapy.Journal of neurovirology · 2018Article
- The HIV-1 transmission bottleneck.Retrovirology · 2017Article
- HIV Trafficking Between Blood and Semen During Early Untreated HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Phylogenetics and Phyloanatomy of HIV/SIV Intra-Host Compartments and Reservoirs: The Key Role of the Central Nervous System.Current HIV research · 2016Review
- Detection of Simian Immunodeficiency Virus in Semen, Urethra, and Male Reproductive Organs during Efficient Highly Active Antiretroviral Therapy.Journal of virology · 2015Article
- Generation and evaluation of clade C simian-human immunodeficiency virus challenge stocks.Journal of virology · 2015Article
- Viral RNA levels and env variants in semen and tissues of mature male rhesus macaques infected with SIV by penile inoculation.PloS one · 2013Article
- Article
- Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions.The Journal of infectious diseases · 2012Article
- Impact of short-term HAART initiated during the chronic stage or shortly post-exposure on SIV infection of male genital organs.PloS one · 2012Article
- Role of donor genital tract HIV-1 diversity in the transmission bottleneck.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.