ArticleTetrahedron2010
Diversification of a β-Lactam Pharmacophore via Allylic C-H Amination: Accelerating Effect of Lewis Acid Co-Catalyst.
Article in Tetrahedron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Asymmetric Synthesis of γ-Amino Alcohols by Copper-Catalyzed Hydroamination.Organic letters · 2019Article
- Synthesis of anti-1,3 Amino Alcohol Motifs via Pd(II)/SOX Catalysis with the Capacity for Stereodivergence.Journal of the American Chemical Society · 2019Article
- Transition-Metal- and Light-Free Directed Amination of Remote Unactivated C(spJournal of the American Chemical Society · 2019Article
- N-Boc amines to oxazolidinones via Pd(II)/bis-sulfoxide/Brønsted acid co-catalyzed allylic C-H oxidation.Journal of the American Chemical Society · 2014Article
- A C-H oxidation approach for streamlining synthesis of chiral polyoxygenated motifs.Tetrahedron · 2013Article
- Catalyst-controlled C-O versus C-N allylic functionalization of terminal olefins.Journal of the American Chemical Society · 2013Article
- Sequential allylic C-H amination/vinylic C-H arylation: a strategy for unnatural amino acid synthesis from α-olefins.Organic letters · 2012Article
- Molecular complexity via C-H activation: a dehydrogenative Diels-Alder reaction.Journal of the American Chemical Society · 2011Article
- Synthetic versatility in C-H oxidation: a rapid approach to differentiated diols and pyrans from simple olefins.Journal of the American Chemical Society · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This report describes the use of Pd(II)/bis-sulfoxide 1 catalyzed intra- and intermolecular allylic C-H amination reactions to rapidly diversify structures containing a sensitive β-lactam core similar to that found in the monobactam antibiotic Aztreonam. Pharmacologically interesting oxazolidinone, oxazinanone, and linear amine motifs are rapidly installed with predictable and high selectivities under conditions that use limiting amounts of substrate. Additionally, we demonstrate for the first time that intramolecular C-H amination processes may be accelerated using catalytic amounts of a Lewis acid co-catalyst [Cr(III)(salen)Cl 2].
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.