ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2011
Do we have any solid evidence of clinical utility about the pathophysiology of schizophrenia?
Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
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- Electroencephalographic Microstates in Schizophrenia and Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Two distinct neuroanatomical subtypes of schizophrenia revealed using machine learning.Brain : a journal of neurology · 2020Article
- The benefit of foresight? An ethical evaluation of predictive testing for psychosis in clinical practice.NeuroImage. Clinical · 2020Article
- Predicting major mental illness: ethical and practical considerations.BJPsych open · 2019Article
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- Article
- Whether "psychosis" is best conceptualized as a continuum or in categories is an empirical, practical and political question.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2016Article
- Dynamic endophenotypes and longitudinal trajectories: capturing changing aspects of development in early psychosis.Journal of psychiatry & neuroscience : JPN · 2016Article
- Cortical folding and the potential for prognostic neuroimaging in schizophrenia.The British journal of psychiatry : the journal of mental science · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A diagnosis of schizophrenia, as in most of psychiatric practice, is made largely by eliciting symptoms with reference to subjective, albeit operationalized, criteria. This diagnosis then provides some rationale for management. Objective diagnostic and therapeutic tests are much more desirable, provided they are reliably measured and interpreted. Definite advances have been made in our understanding of schizophrenia in recent decades, but there has been little consideration of how this information could be used in clinical practice. We review here the potential utility of the strongest and best replicated risk factors for and manifestations of schizophrenia within clinical, epidemiological, cognitive, blood biomarker and neuroimaging domains. We place particular emphasis on the sensitivity, specificity and predictive power of pathophysiological indices for making a diagnosis, establishing an early diagnosis or predicting treatment response in schizophrenia. We conclude that a number of measures currently available have the potential to increase the rigour of clinical assessments in schizophrenia. We propose that the time has come to more fully evaluate these and other well replicated abnormalities as objective potential diagnostic and prognostic guides, and to steer future clinical, therapeutic and nosological research in this direction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.