ArticleNature chemistry2009
Highly dynamic motion of crown ethers along oligolysine peptide chains.
Article in Nature chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 55 citations in OpenAlex.
- The aqueous supramolecular chemistry of crown ethers.Frontiers in chemistry · 2023Review
- Host-Guest Complexes of C-Ethyl-2-methylresorcinarene and AromaticChemistryOpen · 2017Article
- Artificial Molecular Machines.Chemical reviews · 2015Review
- Protein camouflage in cytochrome c-calixarene complexes.Nature chemistry · 2012Article
- Electrospray ionization mass spectrometry: a technique to access the information beyond the molecular weight of the analyte.International journal of analytical chemistry · 2012Article
- Shift reagents for multidimensional ion mobility spectrometry-mass spectrometry analysis of complex peptide mixtures: evaluation of 18-crown-6 ether complexes.Analytical chemistry · 2011Article
- Recognition-mediated activation of therapeutic gold nanoparticles inside living cells.Nature chemistry · 2010Article
- Molecular recognition of organic ammonium ions in solution using synthetic receptors.Beilstein journal of organic chemistry · 2010Article
- Mass spectrometry: tracking molecular mobility.Nature chemistry · 2009Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular mobility has attracted considerable attention in supramolecular chemistry and biochemistry, but the simple question of whether a small molecule can move directly between different binding sites of a multitopic host without intermediate dissociation has not been addressed so far. To study such processes, we consider hydrogen/deuterium exchange experiments on a model system comprising complexes formed between 18-crown-6 and oligolysine peptides. Because direct binding-site hopping is indistinguishable in solution from a dissociation/reassociation mechanism, here we show that the high vacuum of a mass spectrometer offers a unique environment for probing such processes. The highly dynamic motion of crown ethers along oligolysine peptide chains proceeds mechanistically by a simultaneous transfer of the crown ether from its ammonium ion binding site to a nearby amino group together with a proton. Furthermore, the exchange experiments unambiguously reveal the zwitterionic structure of the 18-crown-6/oligolysine complexes, highlighting the versatility and potential of gas-phase experiments for investigating non-covalent interactions.
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Registered trials
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