ArticleNature chemistry2009
Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes.
Article in Nature chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 194 citations in OpenAlex.
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- Transmembrane Transport of cAMP and AMP Using a Two Component Small Molecule Transport System.Angewandte Chemie (International ed. in English) · 2026Article
- Article
- Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors.Chemical reviews · 2023Review
- Cyclo[2]carbazole[2]pyrrole: a preorganized calix[4]pyrrole analogue.Chemical science · 2023Article
- Transmembrane Transport of Bicarbonate by Anion Receptors.ChemPlusChem · 2022Review
- Transition Metal Catalysis Controlled by Hydrogen Bonding in the Second Coordination Sphere.Chemical reviews · 2022Review
- Supramolecular chemistry in lipid bilayer membranes.Chemical science · 2021Review
- Transmembrane Transport of Bicarbonate Unravelled*.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Synthesis and biological activity of squaramido-tethered bisbenzimidazoles as synthetic anion transporters.RSC advances · 2021Article
- Capture and displacement-based release of the bicarbonate anion by calix[4]pyrroles with small rigid straps.Chemical science · 2020Article
- A Novel Genetically Encoded Single Use Sensory Cellular Test System Measures Bicarbonate Concentration Changes in Living Cells.Sensors (Basel, Switzerland) · 2020Article
- Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia.Nature · 2019Article
- Pyrrole N-H Anion Complexes.Coordination chemistry reviews · 2017Article
- Anion Recognition in Water: Recent Advances from a Supramolecular and Macromolecular Perspective.Angewandte Chemie (International ed. in English) · 2016Review
- Anion Exchanger 2 Regulates Dectin-1-Dependent Phagocytosis and Killing of Candida albicans.PloS one · 2016Article
- Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials.Journal of medicinal chemistry · 2015Article
- Valinomycin as a Classical Anionophore: Mechanism and Ion Selectivity.The Journal of membrane biology · 2015Article
- Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization.The Journal of organic chemistry · 2014Article
- Thiosquaramides: pH switchable anion transporters.Chemical science · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bicarbonate is involved in a wide range of biological processes, which include respiration, regulation of intracellular pH and fertilization. In this study we use a combination of NMR spectroscopy and ion-selective electrode techniques to show that the natural product prodigiosin, a tripyrrolic molecule produced by microorganisms such as Streptomyces and Serratia, facilitates chloride/bicarbonate exchange (antiport) across liposomal membranes. Higher concentrations of simple synthetic molecules based on a 4,6-dihydroxyisophthalamide core are also shown to facilitate this antiport process. Although it is well known that proteins regulate Cl(-)/HCO(3)(-) exchange in cells, these results suggest that small molecules may also be able to regulate the concentration of these anions in biological systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.