ArticlePediatric research2011
Perinatal and postnatal expression of Cav1.3 α1D Ca²⁺ channel in the rat heart.
Article in Pediatric research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- C-Terminus of CaCells · 2026Article
- Novel therapeutic cav1.3-C-terminus normalizes L-type calcium current and ejection fraction in ischemia-induced murine heart failure.Biochemical and biophysical research communications · 2025Article
- Role of Cav1.3 Channels in Brain-Heart Interactions: An Unexpected Journey.Biomedicines · 2025Review
- Advanced Atrioventricular Block in Athletes: Prevalence and Role of Anti-Ro/Sjögren Syndrome-Related Antigen A Antibodies.Journal of the American Heart Association · 2024Article
- Pathophysiology of CaFrontiers in physiology · 2023Review
- Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules.Pharmacological reviews · 2022Review
- Autoimmune Calcium Channelopathies and Cardiac Electrical Abnormalities.Frontiers in cardiovascular medicine · 2019Review
- Postnatal developmental changes in the sensitivity of L-type CaPediatric research · 2018Article
- Regulation of CaJournal of molecular and cellular cardiology · 2018Article
- NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Embryonic ionizing radiation exposure results in expression alterations of genes associated with cardiovascular and neurological development, function, and disease and modified cardiovascular function in zebrafish.Frontiers in genetics · 2014Article
- Calreticulin negatively regulates the surface expression of Cav1.3 L-type calcium channel.Biochemical and biophysical research communications · 2013Article
- Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.Pflugers Archiv : European journal of physiology · 2013Article
- Diminished vision in healthy aging is associated with increased retinal L-type voltage gated calcium channel ion influx.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
The novel Cav1.3 (α1D) L-type Ca²⁺ channel plays a significant role in sinoatrial (SA) and atrioventricular (AV) nodes function and in atrial fibrillation. However, the characterization of α1D Ca²⁺ channel during heart development is very limited. We used real-time RT-PCR, Western blotting, and indirect immunostaining to characterize the developmental expression and localization of α1D Ca²⁺ channel in rat hearts. Both protein and mRNA levels of α1D Ca²⁺ channel decreased postnatally. Two forms of α1D Ca²⁺ channel protein (250 and 190 kD) were observed, with the full-length (250 kD) channel protein being predominant in the prenatal stages. Both Western blots and confocal imaging demonstrated that α1D Ca²⁺ channel protein was expressed in both atria and ventricles at fetal and neonatal stages but was absent in the adult ventricles. Interestingly, α1D Ca²⁺ channel was also found at the nucleus/perinucleus of immature but not adult atrial cells. Furthermore, the nuclear staining was reproduced in adult atrial cell line, HL-1 cells, which possess immature properties. The data are first to show that α1D Ca²⁺ channel has unique age-dependent expression profile and subcellular localization in the heart, suggesting a developmental stage-dependent specific function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.