ArticlePediatric research2011
A role for mineralocorticoid receptors in the physiology of the ovine fetus: effects on ACTH and lung liquid composition.
Article in Pediatric research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Use of radiotelemetry to assess perinatal cardiac function in the ovine fetus and newborn.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Sex-Specificity of Mineralocorticoid Target Gene Expression during Renal Development, and Long-Term Consequences.International journal of molecular sciences · 2017Article
- Mineralocorticoid effects in the late gestation ovine fetal lung.Physiological reports · 2014Article
- Diffusion-weighted MR imaging of fetal lung maturation in sheep: effect of prenatal cortisone administration on ADC values.European radiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In the human and ovine fetus, the presence of 11β-hydroxysteroid dehydrogenase 1 allows cortisol and other corticosteroids to act at mineralocorticoid receptors (MRs) in lung and brain. To test the physiologic role of MRs in the late gestation fetus, fetal lambs were infused with a specific MR antagonist for 12 h. Infusion of the MR antagonist significantly increased plasma ACTH and cortisol concentrations. Infusion of the MR antagonist also significantly increased fetal Pco2 and hematocrit, and decreased fetal pH, but did not alter fetal heart rate or blood pressure. Infusion of the MR antagonist altered the ratio of Na⁺ to K⁺ in lung fluid but did not alter the rate of production of lung liquid or the expression of the epithelial sodium channel α or of the Na,K ATPaseα1 in lung. These results suggest that corticosteroids act at MR to regulate ACTH and blood volume and modulate lung fluid composition in the fetus, but basal levels of corticosteroids do not alter lung liquid production rate through effects on MR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.