ArticleInternational journal of toxicology2011
Fetal and neonatal exposure to nicotine disrupts postnatal lung development in rats: role of VEGF and its receptors.
Article in International journal of toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Nicotine Replacement Therapy during Pregnancy and Child Health Outcomes: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- MIF/CD74 axis regulates alveolar epithelial type II cell apoptosis, autophagy, and transdifferentiation in bronchopulmonary dysplasia via the TGFβ1/SMAD4 pathway.Respiratory research · 2025Article
- The causal association between maternal smoking around birth on childhood asthma: A Mendelian randomization study.Frontiers in public health · 2022Article
- Early Life Exposure to Nicotine: Postnatal Metabolic, Neurobehavioral and Respiratory Outcomes and the Development of Childhood Cancers.Toxicological sciences : an official journal of the Society of Toxicology · 2020Review
- In Vitro Consequences of Electronic-Cigarette Flavoring Exposure on the Immature Lung.International journal of environmental research and public health · 2019Article
- Prenatal Exposure to Gestational Nicotine before Neurulation is Detrimental to Neurodevelopment of Wistar Rats' Offspring.The Malaysian journal of medical sciences : MJMS · 2018Article
- Air pollutants and early origins of respiratory diseases.Chronic diseases and translational medicine · 2018Article
- Electronic Cigarettes: Exposure and Use Among Pediatric Populations.Journal of aerosol medicine and pulmonary drug delivery · 2018Review
- The investigation of effect of alpha lipoic acid against damage on neonatal rat lung to maternal tobacco smoke exposure.Toxicology reports · 2018Article
- Implication of Oxidative Stress in Fetal Programming of Cardiovascular Disease.Frontiers in physiology · 2018Review
- Maternal smoke exposure decreases mesenchymal proliferation and modulates Rho-GTPase-dependent actin cytoskeletal signaling in fetal lungs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Electronic cigarette use and exposure in the pediatric population.JAMA pediatrics · 2015Review
- The effects of electronic cigarette emissions on systemic cotinine levels, weight and postnatal lung growth in neonatal mice.PloS one · 2015Article
- Tobacco smoking: patterns, health consequences for adults, and the long-term health of the offspring.Global journal of health science · 2012Article
- Nicotine induced CpG methylation of Pax6 binding motif in StAR promoter reduces the gene expression and cortisol production.Toxicology and applied pharmacology · 2011Article
- Long-term consequences of fetal and neonatal nicotine exposure: a critical review.Toxicological sciences : an official journal of the Society of Toxicology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Many women are unable to quit smoking during pregnancy and therefore are prescribed drugs, including nicotine (nicotine replacement therapy [NRT]), to aid with smoking cessation. However, the consequences to the offspring of pregnant NRT users have not been well studied. The goals of this study were to determine the consequences of fetal and neonatal exposure to nicotine on lung development and function. Female rats were exposed to nicotine for 2 weeks prior to mating until weaning. Lungs were collected from saline and nicotine-treated rats from birth to adulthood to assess postnatal lung structure and function. Although nicotine exposure altered alveolarization at weaning, an effect that resolved by adulthood, it did not affect lung function at any of the ages investigated. However, nicotine exposure significantly decreased lung vascularization. The current study suggests that perinatal exposure to nicotine alters lung development, an effect which may be mediated via decreased vascular endothelial growth factor (VEGF) signaling.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.