ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2011
Identification and molecular analysis of glycosaminoglycans in cutaneous lupus erythematosus and dermatomyositis.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Comparison of hyaluronic acid in patients with rheumatoid arthritis, systemic sclerosis and systemic lupus erythematosus.Biochemia medica · 2021Trial
- Late-Onset Reactions after Hyaluronic Acid Dermal Fillers: A Consensus Recommendation on Etiology, Prevention and Management.Dermatology and therapy · 2024Review
- The Genetic Landscape of Cutaneous Lupus Erythematosus.Frontiers in medicine · 2022Review
- Cutaneous mucinosis of infancy: a rare case of joint involvement.Pediatric rheumatology online journal · 2021Article
- Increased MxA protein expression and dendritic cells in spongiotic dermatitis differentiates dermatomyositis from eczema in a single-center case-control study.Journal of cutaneous pathology · 2021Article
- Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.The Journal of clinical investigation · 2018Article
- Pathophysiology of cutaneous lupus erythematosus.Arthritis research & therapy · 2015Review
- Dominant Th1 and minimal Th17 skewing in discoid lupus revealed by transcriptomic comparison with psoriasis.The Journal of investigative dermatology · 2014Article
- Gottron's papules exhibit dermal accumulation of CD44 variant 7 (CD44v7) and its binding partner osteopontin: a unique molecular signature.The Journal of investigative dermatology · 2012Article
- Identification of specific chondroitin sulfate species in cutaneous autoimmune disease.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Hyaluronic acid in dermatomyositis and polymyositis: relationship with disease and cutaneous lesions.Anais brasileiros de dermatologiaArticle
- Cutaneous mucinosis in mixed connective tissue disease.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Glycosaminoglycans (GAGs), also known histologically as dermal mucin, accumulate in several inflammatory skin conditions. Because different GAG species have distinct immunologic effects, the authors examined two GAGs, hyaluronan (HA) and chondroitin sulfate (CS), using specific stains in cutaneous lupus erythematosus (CLE) and dermatomyositis (DM). In the dermis of one CLE subtype, tumid LE (TLE), they found only increased HA, but both HA and CS were significantly elevated in another CLE subtype, discoid LE (DLE). DM lesional dermis accumulated mainly CS but not HA. The authors then used glycomic gene expression microarrays to assess the expression of HA- and CS-related genes in CLE skin. Real-time quantitative PCR confirmed significantly increased expression of HAS2, CHSY1, and C4ST1 in the combined groups of CLE lesions (n = 8) compared to healthy controls (n = 4). Thus, the increase in HA in CLE presumably results from upregulation of HAS2, whereas CHSY1 and C4ST1 appear to contribute to increased CS. Based on their known immunomodulatory effects in other systems, HA and CS may thus participate in the pathophysiology of these inflammatory skin conditions.
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Registered trials
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