ArticleAmerican journal of respiratory cell and molecular biology2011
Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice.
Article in American journal of respiratory cell and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
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- A murine sinonasal infection model recapitulates key features of clinical chronic rhinosinusitis.Journal of medical microbiology · 2026Article
- Sex-dependent influence of LMAN1 on allergen-induced airway hyperresponsiveness.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Methacholine hyperresponsiveness in mice with house dust mite-induced lung inflammation is not associated with excessive airway constriction ex vivo.Experimental physiology · 2025Article
- Differential protease content of mast cells and the processing of IL-33 inFrontiers in immunology · 2023Article
- Time course of changes in inflammatory and oxidative biomarkers in lung tissue of mice induced by exposure to electronic cigarette aerosol.Toxicology reports · 2022Article
- The magnitude of airway remodeling is not altered by distinct allergic inflammatory responses in BALB/c versus C57BL/6 mice but matrix composition differs.Immunology and cell biology · 2021Article
- Neutrophils Affect IL-33 Processing in Response to the Respiratory AllergenFrontiers in immunology · 2021Article
- Smooth Muscle Hypocontractility and Airway Normoresponsiveness in a Mouse Model of Pulmonary Allergic Inflammation.Frontiers in physiology · 2021Article
- Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis.Clinical and experimental otorhinolaryngology · 2020Article
- Baseline and innate immune response characterization of a Zfp30 knockout mouse strain.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Article
- Environmental Factor-Mediated Transgenerational Inheritance ofFrontiers in immunology · 2020Article
- Mouse Strain-Dependent Difference Toward theFrontiers in immunology · 2020Article
- In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Identification ofGenetics · 2017Article
- Plethysmography Phenotype QTL in Mice Before and After Allergen Sensitization and Challenge.G3 (Bethesda, Md.) · 2016Article
- Early-Life Intranasal Colonization with Nontypeable Haemophilus influenzae Exacerbates Juvenile Airway Disease in Mice.Infection and immunity · 2016Article
- A CCL24-dependent pathway augments eosinophilic airway inflammation in house dust mite-challenged Cd163(-/-) mice.Mucosal immunology · 2016Article
- CD4⁺ and CD8⁺ T cells play a central role in a HDM driven model of allergic asthma.Respiratory research · 2016Article
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
Abstract
Asthma is etiologically and clinically heterogeneous, making the genomic basis of asthma difficult to identify. We exploited the strain-dependence of a murine model of allergic airway disease to identify different genomic responses in the lung. BALB/cJ and C57BL/6J mice were sensitized with the immunodominant allergen from the Dermatophagoides pteronyssinus species of house dust mite (Der p 1), without exogenous adjuvant, and the mice then underwent a single challenge with Der p 1. Allergic inflammation, serum antibody titers, mucous metaplasia, and airway hyperresponsiveness were evaluated 72 hours after airway challenge. Whole-lung gene expression analyses were conducted to identify genomic responses to allergen challenge. Der p 1-challenged BALB/cJ mice produced all the key features of allergic airway disease. In comparison, C57BL/6J mice produced exaggerated Th2-biased responses and inflammation, but exhibited an unexpected decrease in airway hyperresponsiveness compared with control mice. Lung gene expression analysis revealed genes that were shared by both strains and a set of down-regulated genes unique to C57BL/6J mice, including several G-protein-coupled receptors involved in airway smooth muscle contraction, most notably the M2 muscarinic receptor, which we show is expressed in airway smooth muscle and was decreased at the protein level after challenge with Der p 1. Murine strain-dependent genomic responses in the lung offer insights into the different biological pathways that develop after allergen challenge. This study of two different murine strains demonstrates that inflammation and airway hyperresponsiveness can be decoupled, and suggests that the down-modulation of expression of G-protein-coupled receptors involved in regulating airway smooth muscle contraction may contribute to this dissociation.
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