ArticleJPEN. Journal of parenteral and enteral nutrition2011
Low serum citrulline concentration correlates with catheter-related bloodstream infections in children with intestinal failure.
Article in JPEN. Journal of parenteral and enteral nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03105362 (Tolerability of an Amino Acid-based Oral Rehydration Solution in Children With Short Bowel Syndrome), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tolerability of an Amino Acid-based Oral Rehydration Solution in Children With Short Bowel Syndrome
Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Citrulline and albumin as biomarkers for gastrointestinal mucositis in recipients of hematopoietic SCT.Bone marrow transplantation · 2013Trial
- Free amino acid composition of saliva in patients with healthy periodontium and periodontitis.Clinical oral investigations · 2021Article
- Biomarkers of sepsis: time for a reappraisal.Critical care (London, England) · 2020Review
- Nutritional therapy complications in children with ultra-short bowel syndrome include growth deficiency but not cholestasis.Acta paediatrica (Oslo, Norway : 1992) · 2018Article
- Markers of Environmental Enteric Dysfunction Are Associated With Neurodevelopmental Outcomes in Tanzanian Children.Journal of pediatric gastroenterology and nutrition · 2018Article
- Necrotizing enterocolitis is associated with earlier achievement of enteral autonomy in children with short bowel syndrome.Journal of pediatric surgery · 2016Article
- Central line-associated bloodstream infections in neonates with gastrointestinal conditions: developing a candidate definition for mucosal barrier injury bloodstream infections.Infection control and hospital epidemiology · 2014Article
- Serum citrulline as a biomarker of gastrointestinal function during hematopoietic cell transplantation in children.Journal of pediatric gastroenterology and nutrition · 2014Article
- Reduced plasma citrulline levels in low birth weight infants with necrotizing enterocolitis.Journal of clinical laboratory analysis · 2013Article
- Medical update and potential advances in the treatment of pediatric intestinal failure.Current gastroenterology reports · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSerum citrulline concentration is used as a biomarker of enterocyte mass and enteral tolerance, and low serum concentrations are correlated with bacteremia in immunosuppressed adults undergoing hematopoietic stem cell transplant. The authors sought to determine if citrulline was associated with the development of catheter-related bloodstream infections (CRBSIs) in children with intestinal failure.
methodsData were reviewed from 66 children treated in a multidisciplinary intestinal rehabilitation program, who had serum concentration citrulline measured between January 2007 and August 2009. All patients had a diagnosis of intestinal failure requiring parenteral nutrition (PN) support. Exclusion criteria included central venous catheter in situ <30 days, creatinine clearance <20 mL/minute, or a history of organ transplant/immunosuppression.
resultsA total of 15 patients were excluded because of the above criteria. In this cohort of 51 patients, 26 (51%) developed CRBSIs. Both groups were similar in terms of gestational age, diagnosis, nutrition status, and biochemical liver function tests. The mean (± standard deviation [SD]) minimum serum citrulline concentration was significantly lower in patients who developed CRBSIs (6.7 ± 4.6 µmol/L) than in those who did not (11.3 ± 6.4 µmol/L, P = .004). Multivariate logistic regression analysis identified lower minimum serum citrulline concentration and longer central venous catheter duration as independently associated with CRBSI (P = .003 and P = .038, respectively).
conclusionsLow serum citrulline concentration and longer central venous catheter time are independently associated with CRBSI in children with intestinal failure. Serum citrulline concentration may be a useful biomarker to identify patients with intestinal failure who are at high risk of developing a CRBSI.
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