ArticleJPEN. Journal of parenteral and enteral nutrition2011
Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass surgery.
Article in JPEN. Journal of parenteral and enteral nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Weight Loss after Left Gastric Artery Embolization: A Systematic Review and Meta-Analysis.Journal of vascular and interventional radiology : JVIR · 2019Pooled it
- The Effects of Bariatric Surgery on Female Fertility: A Narrative Review.International journal of molecular sciences · 2026Review
- Transforming Treatment: The Impact of Bariatric Surgery on Oral Drug Absorption.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- The Effects of Sleeve Gastrectomy on Blood Pressure, Blood Pressure Variability, and Autonomic Functions in Severely Obese Patients Without Diabetes or Hypertension.Journal of clinical medicine · 2026Article
- Body Composition Changes After Bariatric Surgery: Magnitude, Timing, and Determinants of Excessive Fat-Free Mass Loss.Journal of clinical medicine · 2026Article
- An efficient online peak detection algorithm for synchronized intestinal electrical stimulation and its application for treating diabetes.Medical & biological engineering & computing · 2023Article
- Bariatric Surgery Is Associated with Alcohol-Related Liver Disease and Psychiatric Disorders Associated with AUD.Obesity surgery · 2023Article
- From worms to humans: Understanding intestinal lipid metabolism via model organisms.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2023Review
- Testing for Protein Leverage in Patients with Gastric Bypass: A Pilot Study.Annals of nutrition & metabolism · 2023Article
- Biliopancreatic Limb Length of Small Intestinal Bypass in Non-obese Goto-Kakizaki (GK) Rats Correlates with Gastrointestinal Hormones, Adipokines, and Improvement in Type 2 Diabetes.Obesity surgery · 2021Article
- Obesity, Hypertension, and Bariatric Surgery.Current hypertension reports · 2020Review
- Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss.Scientific reports · 2019Article
- Bariatric Embolization of Arteries for the Treatment of Obesity (BEAT Obesity) Trial: Results at 1 Year.Radiology · 2019Article
- Roux-en-Y gastric bypass compared with equivalent diet restriction: Mechanistic insights into diabetes remission.Diabetes, obesity & metabolism · 2018Article
- Effect of vertical sleeve gastrectomy on alcohol consumption and preferences in dietary obese rats and mice: A plausible role for altered ghrelin signaling.Brain research bulletin · 2018Article
- The endogenous preproglucagon system is not essential for gut growth homeostasis in mice.Molecular metabolism · 2017Article
- Long-Term Body Composition Changes in Women Following Roux-en-Y Gastric Bypass Surgery.JPEN. Journal of parenteral and enteral nutrition · 2017Article
- Comparison of Weight Loss, Ghrelin, and Leptin Hormones After Ligation of Left Gastric Artery and Sleeve Gastrectomy in a Rat Model.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- The Neurobiological Impact of Ghrelin Suppression after Oesophagectomy.International journal of molecular sciences · 2016Review
- Effect on Nitrogen Balance, Thermogenesis, Body Composition, Satiety, and Circulating Branched Chain Amino Acid Levels up to One Year after Surgery: Protocol of a Randomized Controlled Trial on Dietary Protein During Surgical Weight Loss.JMIR research protocols · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundRoux-en-Y gastric bypass (RYGB) imparts long-term weight loss, the mechanisms for which are not well understood. Changes in leptin and gastrointestinal (GI) hormones, including glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and ghrelin, may contribute to the relative success of RYGB compared with conventional weight loss methods. This study evaluated changes in GI hormones and leptin post-RYGB. The study also evaluated whether GI hormones differed after a short-term dose of protein or fat.
methodsGLP-1, PYY, ghrelin, and leptin were assessed in 16 women before RYGB and up to 1 year after RYGB. Plasma was collected before and at several times after a short-term equicaloric dose of protein or fat.
resultsGLP-1 area under the curve (AUC) increased at week 6 and 1 year in the fat beverage (FAT-BEV) group compared with baseline. PYY AUC remained elevated at 1 year in the FAT-BEV group. Ghrelin AUC decreased at week 2, week 6, and 1 year in the protein beverage (PRO-BEV) group compared with baseline. Ghrelin AUC was lower in the PRO-BEV group compared with the FAT-BEV group at week 6. Fasted leptin decreased at all visits in both groups and was lower in the FAT-BEV group compared with the PRO-BEV group at 1 year.
conclusionsChanges from baseline were evident for all GI hormones and leptin; some differences were evident soon after surgery (ghrelin, leptin), whereas others were maintained long term (GLP-1, PYY, ghrelin, leptin). In response to a short-term stimulus, protein suppressed ghrelin and fat potently stimulated GLP-1 and PYY. Future work in this area is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.