ArticleJournal of bacteriology2011
Partial functional replacement of CymA by SirCD in Shewanella oneidensis MR-1.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
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- Cross-regulation of amino acid synthesis and anaerobic electron transfer by MetR-mediated methionine signaling.Journal of bacteriology · 2026Article
- Crp and Arc system directly regulate the transcription of NADH dehydrogenase genes inMicrobiology spectrum · 2025Article
- Overlap and differences between the inward and outward electron transfer pathways in Shewanella oneidensis.FEMS microbiology letters · 2025Article
- A bacterial transcription activator dedicated to the expression of the enzyme catalyzing the first committed step in fatty acid biosynthesis.Nucleic acids research · 2024Article
- Novel Insights on Extracellular Electron Transfer Networks in theMicroorganisms · 2024Article
- Pleiotropic Effects of Hfq on the CytochromeApplied and environmental microbiology · 2022Article
- Comparative genomics reveals electron transfer and syntrophic mechanisms differentiating methanotrophic and methanogenic archaea.PLoS biology · 2022Review
- Promoting Extracellular Electron Transfer ofFrontiers in microbiology · 2021Article
- Towards patterned bioelectronics: facilitated immobilization of exoelectrogenic Escherichia coli with heterologous pili.Microbial biotechnology · 2018Article
- Partially Reciprocal Replacement of FlrA and FlrC in Regulation of Shewanella oneidensis Flagellar Biosynthesis.Journal of bacteriology · 2018Article
- Deep-Sea Bacterium Shewanella piezotolerans WP3 Has Two Dimethyl Sulfoxide Reductases in Distinct Subcellular Locations.Applied and environmental microbiology · 2017Article
- Molecular Underpinnings of Nitrite Effect on CymA-Dependent Respiration in Shewanella oneidensis.Frontiers in microbiology · 2016Article
- Regulation of nitrite resistance of the cytochrome cbb3 oxidase by cytochrome c ScyA in Shewanella oneidensis.MicrobiologyOpen · 2015Article
- Endogenous generation of hydrogen sulfide and its regulation in Shewanella oneidensis.Frontiers in microbiology · 2015Article
- Selenite reduction by Shewanella oneidensis MR-1 is mediated by fumarate reductase in periplasm.Scientific reports · 2014Article
- Identification of a reductive tetrachloroethene dehalogenase in Shewanella sediminis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- Genomic plasticity enables a secondary electron transport pathway in Shewanella oneidensis.Applied and environmental microbiology · 2013Article
- Deciphering the electron transport pathway for graphene oxide reduction by Shewanella oneidensis MR-1.Journal of bacteriology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gammaproteobacterium Shewanella oneidensis MR-1 utilizes a complex electron transfer network composed primarily of c-type cytochromes to respire under anoxic conditions a variety of compounds, including fumarate, nitrate, and dimethyl sulfoxide (DMSO), in addition to the minerals Fe(III) and Mn(IV). Central to several respiratory pathways is CymA, a cytoplasmic membrane-bound tetraheme c-type cytochrome that functions as the major hydroquinone dehydrogenase. To investigate functional redundancy and plasticity in S. oneidensis MR-1 electron transport, we isolated ΔcymA suppressor mutants and characterized one biochemically and genetically. Interestingly, in the characterized ΔcymA suppressor mutant, respiration of fumarate, ferric citrate, and DMSO was restored but that of nitrate was not. The suppression was found to be due to transcriptional activation of sirC and sirD, encoding a periplasmic iron sulfur protein and an integral membrane hydroquinone dehydrogenase, respectively. Biochemical in vitro reconstitution experiments confirmed electron transport between formate and fumarate via fumarate reductase by suppressor membrane fractions. The suppression was found to be caused by insertion of an ISSod1 element upstream of the sirCD transcriptional start site, generating a novel, constitutively active hybrid promoter. This work revealed that adaptation of an alternative electron transfer pathway from quinol to terminal oxidoreductases independent of CymA occurs rapidly in S. oneidensis MR-1.
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