ArticleNucleic acids research2011
The Caenorhabditis elegans intermediate-size transcriptome shows high degree of stage-specific expression.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Small and intermediate size structural RNAs in the unicellular parasiteMicrobial genomics · 2022Article
- Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells.Bioscience reports · 2018Article
- Of dogs and hookworms: man's best friend and his parasites as a model for translational biomedical research.Parasites & vectors · 2018Review
- Analysis of the p53/CEP-1 regulated non-coding transcriptome in C. elegans by an NSR-seq strategy.Protein & cell · 2014Article
- An anoxia-starvation model for ischemia/reperfusion in C. elegans.Journal of visualized experiments : JoVE · 2014Article
- Deep profiling of the novel intermediate-size noncoding RNAs in intraerythrocytic Plasmodium falciparum.PloS one · 2014Article
- Long noncoding RNAs in C. elegans.Genome research · 2012Article
- Regulatory elements of Caenorhabditis elegans ribosomal protein genes.BMC genomics · 2012Article
- A differential sequencing-based analysis of the C. elegans noncoding transcriptome.RNA (New York, N.Y.) · 2012Article
- Identification of intermediate-size non-coding RNAs involved in the UV-induced DNA damage response in C. elegans.PloS one · 2012Article
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11 authors.
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Abstract
Earlier studies have revealed a substantial amount of transcriptional activity occurring outside annotated protein-coding genes of the Caenorhabditis elegans genome. One important fraction of this transcriptional activity relates to intermediate-size (70-500 nt) transcripts (is-ncRNAs) of mostly unknown function. Profiling the expression of this segment of the transcriptome on a tiling array through the C. elegans life cycle identified 5866 hitherto unannotated transcripts. The novel loci were distributed across intronic and intergenic space, with some enrichment toward protein-coding gene termini. The majority of the putative is-ncRNAs showed either stage-specific expression, or distinct developmental variation in their expression levels. More than 200 loci showed male-specific expression, and conserved loci were significantly enriched on the X chromosome, both observations strongly suggesting involvement of is-ncRNAs in sex-specific functions. Half of the novel loci were conserved in other nematodes, and numerous loci showed significant conservational correlations to nearby coding genes. Assuming functional roles for most of the novel loci, the data imply a nematode is-ncRNA tool kit of considerable size and variety.
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