ArticlePsychiatry research2011
Hemispheric comparisons of neuron density in the planum temporale of schizophrenia and nonpsychiatric brains.
Article in Psychiatry research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- The enigma and implications of brain hemispheric asymmetry in neurodegenerative diseases.Brain communications · 2021Review
- Reduced GABA neuron density in auditory cerebral cortex of subjects with major depressive disorder.Journal of chemical neuroanatomy · 2016Article
- Neurophysiological differences between patients clinically at high risk for schizophrenia and neurotypical controls--first steps in development of a biomarker.BMC medicine · 2015Article
- Auditory dysfunction in schizophrenia: integrating clinical and basic features.Nature reviews. Neuroscience · 2015Review
- The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies.Annals of the New York Academy of Sciences · 2015Review
- Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Morphometric differences in planum temporale in schizophrenia and bipolar disorder revealed by statistical analysis of labeled cortical depth maps.Frontiers in psychiatry · 2014Article
- Hemispheric asymmetry of primary auditory cortex and Heschl's gyrus in schizophrenia and nonpsychiatric brains.Psychiatry research · 2013Article
- Neuroimaging schizophrenia: a picture is worth a thousand words, but is it saying anything important?Current psychiatry reports · 2013Review
- Targeting glutamate synapses in schizophrenia.Trends in molecular medicine · 2011Review
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
Postmortem and in vivo studies of schizophrenia frequently reveal reduced cortical volume, but the underlying cellular abnormalities are incompletely defined. One influential hypothesis, especially investigated in Brodmann's area 9 of prefrontal cortex, is that the number of neurons is normal, and the volume change is caused by reduction of the surrounding neuropil. However, studies have differed on whether the cortex has the increased neuron density that is predicted by this hypothesis. In a recent study of bilateral planum temporale (PT), we reported smaller volume and width of the outer cortex (layers I-III), especially in the left hemisphere, among subjects with schizophrenia. In the present study, we measured neuron density and size in the same PT samples, and also in prefrontal area 9 of the same brains. In the PT, separate stereological measurements were made in layers II, IIIc, and VI, whereas area 9 was sampled in layer IIIb-c. In both cortical regions, there was no significant effect of schizophrenia on neuronal density or size. There was, nevertheless, a trend-level right>left hemispheric asymmetry of neuron density in the PT, which may partially explain the previously reported left>right asymmetry of cortical width. In schizophrenia, our findings suggest that closer packing of neurons may not always explain reduced cortical volume, and subtly decreased neuron number may be a contributing factor.
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