ArticleInternational journal of antimicrobial agents2011
Combined treatment of Pseudomonas aeruginosa biofilm with lactoferrin and xylitol inhibits the ability of bacteria to respond to damage resulting from lactoferrin iron chelation.
Article in International journal of antimicrobial agents, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Biological and clinical significance of iron inJournal of bacteriology · 2026Review
- Forging biofilms: metal-induced microbial responses in biofilm formation.Journal of bacteriology · 2025Review
- Alteration of oral microbial biofilms by sweeteners.Biofilm · 2024Review
- Activity of Phage-Lactoferrin Mixture against Multi Drug ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Recent Advances in Iron Chelation and Gallium-Based Therapies for Antibiotic Resistant Bacterial Infections.International journal of molecular sciences · 2021Review
- Ultrasound-mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge.Microbial biotechnology · 2020Review
- PLGA/xylitol nanoparticles enhance antibiofilm activityRSC advances · 2019Article
- Current Status of In Vitro Models and Assays for Susceptibility Testing for Wound Biofilm Infections.Biomedicines · 2019Review
- Effect of Wine Wastes Extracts on the Viability and Biofilm Formation ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics.Microbiology and molecular biology reviews : MMBR · 2014Review
- Mini-review: Lactoferrin: a bioinspired, anti-biofilm therapeutic.Biofouling · 2013Review
- The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for Polymicrobial Infected Wounds.Frontiers in immunology · 2013Article
- Development and application of a polymicrobial, in vitro, wound biofilm model.Journal of applied microbiology · 2012Article
- Effects of Poly-N-isopropylacrylamide Microgels Containing Antibiofilm Substances onAvicenna journal of medical biotechnologyArticle
- Symptom assessment after nasal irrigation with xylitol in the postoperative period of endonasal endoscopic surgery.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
With an ageing and ever more obese population, chronic wounds such as diabetic ulcers, pressure ulcers and venous leg ulcers are an increasingly relevant medical concern. Identification of bacterial biofilm contamination as a major contributor to non-healing wounds demands biofilm-targeted strategies to manage chronic wounds. Pseudomonas aeruginosa has been identified as a principal biofilm-forming opportunistic pathogen in chronic wounds. The innate immune molecule lactoferrin and the rare sugar alcohol xylitol have been demonstrated to be co-operatively efficacious against P. aeruginosa biofilms in vitro. Data presented here propose a model for the molecular mechanism behind this co-operative antimicrobial effect. Lactoferrin iron chelation was identified as the primary means by which lactoferrin destabilises the bacterial membrane. By microarray analysis, 183 differentially expressed genes of ≥ 1.5-fold difference were detected. Interestingly, differentially expressed transcripts included the operon encoding components of the pyochelin biosynthesis pathway. Furthermore, siderophore detection verified that xylitol is the component of this novel synergistic treatment that inhibits the ability of the bacteria to produce siderophores under conditions of iron restriction. The findings presented here demonstrate that whilst lactoferrin treatment of P. aeruginosa biofilms results in destabilisation of the bacterial cell membrane though iron chelation, combined treatment with lactoferrin and xylitol inhibits the ability of P. aeruginosa biofilms to respond to environmental iron restriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.