ArticleHeart rhythm2011
Increased left ventricular mass and decreased left ventricular systolic function have independent pathways to ventricular arrhythmogenesis in coronary artery disease.
Article in Heart rhythm, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 82 citations in OpenAlex.
- Association Between Admission Blood Pressure and In-hospital Mortality and Long-term Mortality of Patients With ST-elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A China Acute Myocardial Infarction Registry Study.Reviews in cardiovascular medicine · 2025Article
- Observational study of sudden cardiac arrest risk (OSCAR): Rationale and design of an electronic health records cohort.International journal of cardiology. Heart & vasculature · 2025Article
- Diagnosis and Management of Hypertensive Heart Disease: Incorporating 2023 European Society of Hypertension and 2024 European Society of Cardiology Guideline Updates.Journal of cardiovascular development and disease · 2025Review
- Sex and Gender Differences in Ventricular Arrhythmias.US cardiology · 2023Review
- Kidney function and the risk of sudden cardiac death in the general population.Clinical kidney journal · 2022Article
- Cardiac magnetic resonance identifies raised left ventricular filling pressure: prognostic implications.European heart journal · 2022Article
- Prediction of Sudden Cardiac Death Manifesting With Documented Ventricular Fibrillation or Pulseless Ventricular Tachycardia.JACC. Clinical electrophysiology · 2022Article
- Recent Non-Invasive Parameters to Identify Subjects at High Risk of Sudden Cardiac Death.Journal of clinical medicine · 2022Review
- Left ventricular hypertrophy and sudden cardiac death.Heart failure reviews · 2022Review
- Article
- Relations Between Cardiac Magnetic Resonance Imaging-Derived Left Ventricular Mass, Early Repolarization, and Cardiovascular Events (from the Dallas Heart Study).The American journal of cardiology · 2021Article
- Genetic Variants Associated With Sudden Cardiac Death in Victims With Single Vessel Coronary Artery Disease and Left Ventricular Hypertrophy With or Without Fibrosis.Frontiers in cardiovascular medicine · 2021Article
- Impact of obstructive sleep apnea on left ventricular mass index in men with coronary artery disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Antihypertensive therapy and sudden cardiac death, should we expect the unexpected?Journal of human hypertension · 2020Review
- Article
- Myocardial Microvascular Dysfunction in Rheumatoid ArthritisCirculation. Cardiovascular imaging · 2019Article
- Nocturnal systolic hypertension is a risk factor for cardiac damage in the untreated masked hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Structural and Physiological Imaging to Predict the Risk of Lethal Ventricular Arrhythmias and Sudden Death.JACC. Cardiovascular imaging · 2019Review
- Sympathetic Activation in Hypertensive Chronic Kidney Disease - A Stimulus for Cardiac Arrhythmias and Sudden Cardiac Death?Frontiers in physiology · 2019Review
- Pathoanatomic Findings Associated With Duty-Related Cardiac Death in US Firefighters: A Case-Control Study.Journal of the American Heart Association · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFollowing myocardial infarction, individual patients can have wide variations in the extent of left ventricular systolic dysfunction (LVSD) and increased left ventricular (LV) mass. Both affect the risk for sudden cardiac death, but only LV ejection fraction is used for risk prediction.
objectiveThe purpose of this study was to evaluate the independent as well as the additive contributions of increased LV mass and decreased LV ejection fraction to sudden cardiac death in the general population.
methodsIn the ongoing Oregon Sudden Unexpected Death Study, we studied consecutive SCD cases (n = 191) and coronary artery disease controls (n = 203) from the Portland, Oregon, metropolitan area (population approximately 1,000,000; 2002-2008). Comparisons of echocardiographic LV mass obtained prior and unrelated to sudden cardiac death (SCD) were conducted, and a logistic regression model was used to evaluate the relationship between SCD, severe LVSD, LV mass, and other relevant clinical variables.
resultsIn a multivariate model, both severe LVSD and left ventricular hypertrophy (LVH) were associated with increased SCD risk (odds ratio [OR] 1.9, 95% confidence interval [CI] 1.1-3.2 for severe LVSD; OR 1.8, 95% CI 1.1-2.9 for LVH). In patients with coexisting severe LVSD and LVH, risk of SCD was additive (OR 3.5, 95% CI 1.7-7.2). In the same model, increased age, atrial fibrillation/flutter, elevated creatinine, and diabetes independently increased risk, and use of angiotensin receptor blockers attenuated risk.
conclusionReduced LV ejection fraction and increased LV mass had independent and additive effects on risk of sudden death. Despite the significant overlap between the two conditions, these findings point toward the existence of independent mechanistic pathways for ventricular arrhythmias that occur due to LVSD and LVH.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.