ReviewSeminars in cell & developmental biology2011
X-chromosome epigenetic reprogramming in pluripotent stem cells via noncoding genes.
Review in Seminars in cell & developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Antisense Oligonucleotide-MediatedAnimals : an open access journal from MDPI · 2026Article
- Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities.Current opinion in neurobiology · 2016Review
- X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells.Stem cell reviews and reports · 2015Review
- Tapping Stem Cells to Target AMD: Challenges and Prospects.Journal of clinical medicine · 2015Review
- The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome.Science (New York, N.Y.) · 2013Article
- Long noncoding RNAs: new players in the molecular mechanism for maintenance and differentiation of pluripotent stem cells.Stem cells and development · 2013Review
- Pivots of pluripotency: the roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells.Biochimica et biophysica acta · 2013Review
- Epigenetics: judge, jury and executioner of stem cell fate.Epigenetics · 2012Review
- Solving the "X" in embryos and stem cells.Stem cells and development · 2012Review
- Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.Cell stem cell · 2012Article
- Dosage compensation of the sex chromosomes.Annual review of genetics · 2012Review
- Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer.American journal of translational research · 2012Article
- Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders.PloS one · 2012Article
- X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells.Human genetics · 2011Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Acquisition of the pluripotent state coincides with epigenetic reprogramming of the X-chromosome. Female embryonic stem cells are characterized by the presence of two active X-chromosomes, cell differentiation by inactivation of one of the two Xs, and induced pluripotent stem cells by reactivation of the inactivated X-chromosome in the originating somatic cell. The tight linkage between X- and stem cell reprogramming occurs through pluripotency factors acting on noncoding genes of the X-inactivation center. This review article will discuss the latest advances in our understanding at the molecular level. Mouse embryonic stem cells provide a standard for defining the pluripotent ground state, which is characterized by low levels of the noncoding Xist RNA and the absence of heterochromatin marks on the X-chromosome. Human pluripotent stem cells, however, exhibit X-chromosome epigenetic instability that may have implications for their use in regenerative medicine. XIST RNA and heterochromatin marks on the X-chromosome indicate whether human pluripotent stem cells are developmentally 'naïve', with characteristics of the pluripotent ground state. X-chromosome status and determination thereof via noncoding RNA expression thus provide valuable benchmarks of the epigenetic quality of pluripotent stem cells, an important consideration given their enormous potential for stem cell therapy.
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Registered trials
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