ReviewBiochimica et biophysica acta2011
Cilium, centrosome and cell cycle regulation in polycystic kidney disease.
Review in Biochimica et biophysica acta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Therapeutic Potential of Ketogenic Interventions for Autosomal-Dominant Polycystic Kidney Disease: A Systematic Review.Nutrients · 2024Pooled it
- Computational study of biomechanical drivers of renal cystogenesis.Biomechanics and modeling in mechanobiology · 2023Article
- Kinase-anchoring proteins in ciliary signal transduction.The Biochemical journal · 2021Review
- Roles for ELMOD2 and Rootletin in ciliogenesis.Molecular biology of the cell · 2021Article
- Implications of the PAPP-A-IGFBP-IGF-1 pathway in the pathogenesis and treatment of polycystic kidney disease.Cellular signalling · 2020Review
- Integrin-βAmerican journal of physiology. Renal physiology · 2020Article
- Genome-wide suppressor screen identifies USP35/USP38 as therapeutic candidates for ciliopathies.JCI insight · 2019Article
- The toxic effect of cytostatics on primary cilia frequency and multiciliation.Journal of cellular and molecular medicine · 2019Article
- Autosomal dominant polycystic kidney disease: Disrupted pathways and potential therapeutic interventions.Journal of cellular physiology · 2019Review
- Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.PLoS biology · 2019Article
- Polycystic kidney disease.Nature reviews. Disease primers · 2018Review
- Modeling Renal Disease "On the Fly".BioMed research international · 2018Review
- Emerging concepts in biliary repair and fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- The Genetic and Cellular Basis of Autosomal Dominant Polycystic Kidney Disease-A Primer for Clinicians.Frontiers in pediatrics · 2017Review
- Heterotrimeric G protein signaling in polycystic kidney disease.Physiological genomics · 2016Review
- Translational research in ADPKD: lessons from animal models.Nature reviews. Nephrology · 2014Review
- Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression.The American journal of pathology · 2014Article
- Coevolution reveals a network of human proteins originating with multicellularity.Molecular biology and evolution · 2013Article
- CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD.Cell cycle (Georgetown, Tex.) · 2012Article
- Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling.Current biology : CB · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Polycystic kidney disease is the defining condition of a group of common life-threatening genetic disorders characterized by the bilateral formation and progressive expansion of renal cysts that lead to end stage kidney disease. Although a large body of information has been acquired in the past years about the cellular functions that characterize the cystic cells, the mechanisms triggering the cystogenic conversion are just starting to emerge. Recent findings link defects in ciliary functions, planar cell polarity pathway, and centrosome integrity in early cystic development. Many of the signals dysregulated during cystogenesis may converge on the centrosome for its central function as a structural support for cilia formation and a coordinator of protein trafficking, polarity, and cell division. Here, we will discuss the contribution of proliferation, cilium and planar cell polarity to the cystic signal and will analyze in particular the possible role that the basal bodies/centrosome may play in the cystogenetic mechanisms. This article is part of a Special Issue entitled: Polycystic Kidney Disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.