ArticleImmunity2011
A molecular basis for NKT cell recognition of CD1d-self-antigen.
Article in Immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 130 citations in OpenAlex.
- Sideways lipid presentation by the antigen-presenting molecule CD1c.Nature communications · 2025Article
- Sideways lipid presentation by the antigen-presenting molecule CD1c.bioRxiv : the preprint server for biology · 2025Article
- Three-Dimensional Modeling ofAntibodies (Basel, Switzerland) · 2025Article
- Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C-MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies.Cancer research · 2025Article
- Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses.The Journal of experimental medicine · 2023Article
- CD1 displays its own negative regulators.Current opinion in immunology · 2023Review
- Markers and makers of NKT17 cells.Experimental & molecular medicine · 2023Review
- Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR).Scientific reports · 2022Article
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- The Role of Lipids in Allergic Sensitization: A Systematic Review.Frontiers in molecular biosciences · 2022Article
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- Type I Natural Killer T Cells as Key Regulators of the Immune Response to Infectious Diseases.Clinical microbiology reviews · 2021Review
- CD1a function in human skin disease.Molecular immunology · 2021Review
- Human skin is colonized by T cells that recognize CD1a independently of lipid.The Journal of clinical investigation · 2021Article
- Natural Killer T Lymphocytes Integrate Innate Sensory Information and Relay Context to Effector Immune Responses.Critical reviews in immunology · 2021Review
- Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Recent advances in iNKT cell development.F1000Research · 2020Review
- Metabolic Triggers of Invariant Natural Killer T-Cell Activation during Sterile Autoinflammatory Disease.Critical reviews in immunology · 2020Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted microbial and self-lipid antigens, although the molecular basis of self-CD1d recognition is unclear. Here, we have characterized NKT TCR recognition of CD1d molecules loaded with natural self-antigens (Ags) and report the 2.3 Å resolution structure of an autoreactive NKT TCR-phosphatidylinositol-CD1d complex. NKT TCR recognition of self- and foreign antigens was underpinned by a similar mode of germline-encoded recognition of CD1d. However, NKT TCR autoreactivity is mediated by unique sequences within the non-germline-encoded CDR3β loop encoding for a hydrophobic motif that promotes self-association with CD1d. Accordingly, NKT cell autoreactivity may arise from the inherent affinity of the interaction between CD1d and the NKT TCR, resulting in the recognition of a broad range of CD1d-restricted self-antigens. This demonstrates that multiple self-antigens can be recognized in a similar manner by autoreactive NKT TCRs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.