ReviewInsect biochemistry and molecular biology2011
Bacillus thuringiensis: A story of a successful bioinsecticide.
Review in Insect biochemistry and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 334 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
334 citing papers in PubMed, 1,106 citations in OpenAlex.
- C-Terminal Regions of Insecticidal Cry Toxins Form Amyloid Fibrils Affecting Metabolism of Insect Cells.International journal of molecular sciences · 2026Article
- Paradigm shift formBio · 2026Article
- Harnessing Multifunctional Bacillus thuringiensis for Plant Growth Promotion and Biocontrol Potential Against Spodoptera frugiperda.Journal of basic microbiology · 2026Article
- Evaluation of Escherichia coli-derived Silver Nanoparticles for Aedes Vector Control in Southern India.Acta parasitologica · 2026Article
- Bacillus thuringiensis pathogenicity islands encode regulatory circuits controlling insecticidal Cry toxin expression during vegetative growth.PLoS pathogens · 2026Article
- A Mechanistic Model of Cry2Ab12 Toxicity AgainstToxins · 2026Article
- Lipopeptides efficiently disperse spore crystal aggregates in Bacillus thuringiensis israelensis.Applied microbiology and biotechnology · 2026Article
- Article
- Microbial Pressure and Social Immunity: Bumble Bees Increase Brood Hygiene After Exposure to aEcology and evolution · 2026Article
- Three Decades of China's Bt Cotton: Achievements and Insights.Plant biotechnology journal · 2026Review
- V-ATPase A Is a Key Protein Involved in the Toxicity ofInsects · 2026Article
- Discovery of farnesal from a wild cucumber landrace enables eco-compatible biopesticide development against aphids.Nature communications · 2026Article
- Identification, expression, and insecticidal activity analysis of a novel cry toxin gene from Bacillus thuringiensis Gxun777-1.World journal of microbiology & biotechnology · 2026Article
- Fusion protein based strategies for developing insect-resistant crops.Functional & integrative genomics · 2026Review
- Synergistic integration of CRISPR/Cas and nanozymes in next-generation biosensors for ultrasensitive bacterial detection.Mikrochimica acta · 2026Review
- Knockout of aminopeptidase N3 confers resistance to low concentrations of Bacillus thuringiensis Cry4Ba protoxin in Aedes aegypti.Parasites & vectors · 2026Article
- Review
- The Entomotoxic Fungal LectinJournal of agricultural and food chemistry · 2026Article
- Regulatory diversity in Bacillus thuringiensis cry genes reveals flexible evolutionary strategies for in vivo toxin expression.PLoS pathogens · 2026Article
- Generation of an Insecticidal Human Domain Antibody from a Phage Library TargetingCurrent issues in molecular biology · 2026Article
274 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Bacillus thuringiensis (Bt) bacteria are insect pathogens that rely on insecticidal pore forming proteins known as Cry and Cyt toxins to kill their insect larval hosts. At least four different non-structurally related families of proteins form the Cry toxin group of toxins. The expression of certain Cry toxins in transgenic crops has contributed to an efficient control of insect pests resulting in a significant reduction in chemical insecticide use. The mode of action of the three domain Cry toxin family involves sequential interaction of these toxins with several insect midgut proteins facilitating the formation of a pre-pore oligomer structure and subsequent membrane insertion that leads to the killing of midgut insect cells by osmotic shock. In this manuscript we review recent progress in understanding the mode of action of this family of proteins in lepidopteran, dipteran and coleopteran insects. Interestingly, similar Cry-binding proteins have been identified in the three insect orders, as cadherin, aminopeptidase-N and alkaline phosphatase suggesting a conserved mode of action. Also, recent data on insect responses to Cry toxin attack is discussed. Finally, we review the different Bt based products, including transgenic crops, that are currently used in agriculture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.