ArticleBMC genetics2011
Comparing self-reported ethnicity to genetic background measures in the context of the Multi-Ethnic Study of Atherosclerosis (MESA).
Article in BMC genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Genetic Variants Associated With the Biochemical Response to Vitamin D3 in the Multi-Ethnic Study of Atherosclerosis.The Journal of clinical endocrinology and metabolism · 2025Trial
- Serum IgA isotypes are associated with percent emphysema, wall thickness and lung function decline.Thorax · 2025Article
- Lean body mass and the cardiorespiratory phenotype: An ethnic-specific relationship in Hans Chinese women and men.Journal of cachexia, sarcopenia and muscle · 2024Article
- The Chinese cardiorespiratory and circulatory system at work in women and men: a case-control study.The Lancet regional health. Western Pacific · 2024Article
- Blood Levels of Angiotensinogen and Hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA).Journal of the American College of Cardiology · 2023Article
- Greater genetic diversity is needed in human pluripotent stem cell models.Nature communications · 2022Article
- Article
- Race, Ancestry, and Vitamin D Metabolism: The Multi-Ethnic Study of Atherosclerosis.The Journal of clinical endocrinology and metabolism · 2020Article
- Importance of Genetic Studies of Cardiometabolic Disease in Diverse Populations.Circulation research · 2020Review
- Emerging Concepts in Precision Medicine and Cardiovascular Diseases in Racial and Ethnic Minority Populations.Circulation research · 2019Review
- Improving Dietary Behavior Among Ethnic Minority Women in Denmark: A Feasibility Study Based on a Participatory and Culturally Adapted Intervention.International journal of environmental research and public health · 2019Article
- Differences in Natriuretic Peptide Levels by Race/Ethnicity (From the Multi-Ethnic Study of Atherosclerosis).The American journal of cardiology · 2017Observational
- Interactive effects of BDNF Val66Met genotype and trauma on limbic brain anatomy in childhood.European child & adolescent psychiatry · 2016Article
- Amygdala responses to salient social cues vary with oxytocin receptor genotype in youth.Neuropsychologia · 2015Article
- Article
- Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest.Heart rhythm · 2014Article
- HAART-associated dyslipidemia varies by biogeographical ancestry in the multicenter AIDS cohort study.AIDS research and human retroviruses · 2013Article
- Genetic admixture and obesity: recent perspectives and future applications.Human heredity · 2013Review
- An exploration of the serotonin system in antisocial boys with high levels of callous-unemotional traits.PloS one · 2013Article
- Estimating ancestral proportions in a multi-ethnic US sample: implications for studies of admixed populations.Human genomics · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundQuestions remain regarding the utility of self-reported ethnicity (SRE) in genetic and epidemiologic research. It is not clear whether conditioning on SRE provides adequate protection from inflated type I error rates due to population stratification and admixture. We address this question using data obtained from the Multi-Ethnic Study of Atherosclerosis (MESA), which enrolled individuals from 4 self-reported ethnic groups. We compare the agreement between SRE and genetic based measures of ancestry (GBMA), and conduct simulation studies based on observed MESA data to evaluate the performance of each measure under various conditions.
resultsFour clusters are identified using 96 ancestry informative markers. Three of these clusters are well delineated, but 30% of the self-reported Hispanic-Americans are misclassified. We also found that MESA SRE provides type I error rates that are consistent with the nominal levels. More extensive simulations revealed that this finding is likely due to the multi-ethnic nature of the MESA. Finally, we describe situations where SRE may perform as well as a GBMA in controlling the effect of population stratification and admixture in association tests.
conclusionsThe performance of SRE as a control variable in genetic association tests is more nuanced than previously thought, and may have more value than it is currently credited with, especially when smaller replication studies are being considered in multi-ethnic samples.
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