ArticleEMBO molecular medicine2011
Quantitative tracking of T cell clones after haematopoietic stem cell transplantation.
Article in EMBO molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 67 citations in OpenAlex.
- T Cell Thoughts.Immunological reviews · 2026Review
- Article
- T-Cell Receptor Sequences Identify Combined Coxsackievirus-International journal of molecular sciences · 2024Article
- Targeted depletion of TRBV9Nature medicine · 2023Article
- Selected memory T cells infused post-haploidentical hematopoietic stem cell transplantation persist and hyperexpand.Blood advances · 2023Article
- SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19.Nature communications · 2023Article
- Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.Nature communications · 2022Article
- High-throughput and single-cell T cell receptor sequencing technologies.Nature methods · 2021Review
- CDR3 and V genes show distinct reconstitution patterns in T cell repertoire post-allogeneic bone marrow transplantation.Immunogenetics · 2021Article
- Ultra-efficient sequencing of T Cell receptor repertoires reveals shared responses in muscle from patients with Myositis.EBioMedicine · 2020Article
- A Framework for Annotation of Antigen Specificities in High-Throughput T-Cell Repertoire Sequencing Studies.Frontiers in immunology · 2019Article
- RNA sequencing identifies clonal structure of T-cell repertoires in patients with adult T-cell leukemia/lymphoma.NPJ genomic medicine · 2019Article
- Functional TCR T cell screening using single-cell droplet microfluidics.Lab on a chip · 2018Article
- Immune rebound associates with a favorable clinical response to autologous HSCT in systemic sclerosis patients.Blood advances · 2018Article
- Optimized Peptide-MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells.Frontiers in immunology · 2018Article
- T Cell Receptor Profiling in Type 1 Diabetes.Current diabetes reports · 2017Review
- Tracking T-cell immune reconstitution after TCRαβ/CD19-depleted hematopoietic cells transplantation in children.Leukemia · 2017Article
- Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells.Science immunology · 2017Article
- Methodologic Considerations in the Application of Next-Generation Sequencing of Human TRB Repertoires for Clinical Use.The Journal of molecular diagnostics : JMD · 2017Article
- Autoimmunity and the microbiome: T-cell receptor mimicry of "self" and microbial antigens mediates self tolerance in holobionts: The concepts of "holoimmunity" (TcR-mediated tolerance for the holobiont) and "holoautoimmunity" (loss of tolerance for the holobiont) are introduced.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autologous haematopoietic stem cell transplantation is highly efficient for the treatment of systemic autoimmune diseases, but its consequences for the immune system remain poorly understood. Here, we describe an optimized RNA-based technology for unbiased amplification of T cell receptor beta-chain libraries and use it to perform the first detailed, quantitative tracking of T cell clones during 10 months after transplantation. We show that multiple clones survive the procedure, contribute to the immune response to activated infections, and form a new skewed and stable T cell receptor repertoire.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.