ArticleSmall (Weinheim an der Bergstrasse, Germany)2011
Surface-tension-driven gradient generation in a fluid stripe for bench-top and microwell applications.
Article in Small (Weinheim an der Bergstrasse, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- A simple layer-stacking technique to generate biomolecular and mechanical gradients in photocrosslinkable hydrogels.Biofabrication · 2019Article
- Gradient nanocomposite hydrogels for interface tissue engineering.Nanomedicine : nanotechnology, biology, and medicine · 2018Article
- Directional Movement of Droplets in Grooves: Suspended or Immersed?Scientific reports · 2016Article
- On-demand, competing gradient arrays for neutrophil chemotaxis.Lab on a chip · 2014Article
- Multi-gradient hydrogels produced layer by layer with capillary flow and crosslinking in open microchannels.Lab on a chip · 2012Article
- Designer hydrophilic regions regulate droplet shape for controlled surface patterning and 3D microgel synthesis.Small (Weinheim an der Bergstrasse, Germany) · 2012Article
- Biomimetic tissues on a chip for drug discovery.Drug discovery today · 2012Review
- An integrated microfluidic device for two-dimensional combinatorial dilution.Lab on a chip · 2011Article
- Anisotropic material synthesis by capillary flow in a fluid stripe.Biomaterials · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
A simple and inexpensive method is presented employing passive mechanisms to generate centimeters-long gradients of molecules and particles in under a second with only a coated glass slide and a micropipette. A drop of solution is pipetted onto a fluid stripe held in place on a glass slide by a hydrophobic boundary. The resulting difference in curvature pressure drives the flow and creates a concentration gradient by convection. Experiments and theoretical models characterize the flows and gradient profiles and their dependence on the fluid volumes, properties, and stripe geometry. A bench-top rapid prototyping method is outlined to allow the user to design and fabricate the coated slides using only tape and hydrophobic spray. The rapid prototyping method is compatible with microwell arrays, allowing soluble gradients to be applied to cells in shear-protected microwells. The method's simplicity makes it accessible to virtually any researcher or student and its use of passive mechanisms makes it ideal for field use and compatible with point-of-care and global health initiatives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.