ArticleExperimental brain research2011
Sinusoidal galvanic vestibular stimulation (sGVS) induces a vasovagal response in the rat.
Article in Experimental brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 41 citations in OpenAlex.
- Polarity-Dependent Effects of Sinusoidal Galvanic Vestibular Stimulation on Cardiovascular Responses During Cognitive Load.Sensors (Basel, Switzerland) · 2026Article
- Vestibulo-sympathetic interaction and otolith function in postural orthostatic tachycardia syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Otolith Irregular Fiber Stimulation Elicits a Rostro-Caudal Activity Gradient in the Vestibular Nuclear Complex and Both Direct and Indirect Afferent Pathways of the Vestibulocerebellum.The Journal of comparative neurology · 2025Article
- Sensorineural correlates of failed functional recovery after natural regeneration of vestibular hair cells in adult mice.Frontiers in neurology · 2024Article
- Augmented ocular vestibular-evoked myogenic potentials in postural orthostatic tachycardia syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Binocular 3-D otolith-ocular reflexes: responses of chinchillas to natural and prosthetic stimulation after ototoxic injury and vestibular implantation.Journal of neurophysiology · 2023Article
- Time-varying caloric vestibular stimulation for the treatment of neurodegenerative disease.Frontiers in aging neuroscience · 2022Article
- Predicting Vasovagal Responses: A Model-Based and Machine Learning Approach.Frontiers in neurology · 2021Article
- Pulsed Infrared Stimulation of Vertical Semicircular Canals Evokes Cardiovascular Changes in the Rat.Frontiers in neurology · 2021Article
- The Acute Effects of Time-Varying Caloric Vestibular Stimulation as Assessed With fMRI.Frontiers in systems neuroscience · 2021Article
- Editorial: Vestibular Contributions to Health and Disease, Volume II-Dedicated to Bernard Cohen.Frontiers in neurology · 2021Article
- The Scientific Contributions of Bernard Cohen (1929-2019).Frontiers in neurology · 2020Review
- Vestibular, locomotor, and vestibulo-autonomic research: 50 years of collaboration with Bernard Cohen.Journal of neurophysiology · 2020Review
- Editorial: Vestibular Contributions to Health and Disease.Frontiers in neurology · 2018Article
- The response of the vestibulosympathetic reflex to linear acceleration in the rat.Journal of neurophysiology · 2016Article
- Galvanic Vestibular Stimulation: Cellular Substrates and Response Patterns of Neurons in the Vestibulo-Ocular Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Glutamate and GABA in Vestibulo-Sympathetic Pathway Neurons.Frontiers in neuroanatomy · 2016Article
- A Model of Blood Pressure, Heart Rate, and Vaso-Vagal Responses Produced by Vestibulo-Sympathetic Activation.Frontiers in neuroscience · 2016Article
- Dysfunctional vestibular system causes a blood pressure drop in astronauts returning from space.Scientific reports · 2015Article
- Sexual dimorphism in gene expression after aneurysmal subarachnoid hemorrhage.Neurological research · 2015Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Blood pressure (BP) and heart rate (HR) were studied in isoflurane-anesthetized Long-Evans rats during sinusoidal galvanic vestibular stimulation (sGVS) and sinusoidal oscillation in pitch to characterize vestibular influences on autonomic control of BP and HR. sGVS was delivered binaurally via Ag/AgCl needle electrodes inserted over the mastoids at stimulus frequencies 0.008-0.4 Hz. Two processes affecting BP and HR were induced by sGVS: 1) a transient drop in BP (≈15-20 mmHg) and HR (≈3 beat*s(-1)), followed by a slow recovery over 1-6 min; and 2) inhibitory modulations in BP (≈4.5 mmHg/g) and HR (≈0.15 beats*s(-1)/g) twice in each stimulus cycle. The BP and HR modulations were approximately in-phase with each other and were best evoked by low stimulus frequencies. A wavelet analysis indicated significant energies in BP and HR at scales related to twice and four times the stimulus frequency bands. BP and HR were also modulated by oscillation in pitch at frequencies 0.025-0.5 Hz. Sensitivities at 0.025 Hz were ≈4.5 mmHg/g (BP) and ≈0.17 beat*s(-1)/g (HR) for pitches of 20-90°. The tilt-induced BP and HR modulations were out-of-phase, but the frequencies at which responses were elicited by tilt and sGVS were the same. The results show that the sGVS-induced responses, which likely originate in the otolith organs, can exert a powerful inhibitory effect on both BP and HR at low frequencies. These responses have a striking resemblance to human vasovagal responses. Thus, sGVS-activated rats can potentially serve as a useful experimental model of the vasovagal response in humans.
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