ArticleDigestive diseases and sciences2011
Deficit of gammadelta T lymphocytes in the peripheral blood of patients with Crohn's disease.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Immune dysregulation, apoptosis impairment, and enhanced seroreactivity to Anisakis simplex in Crohn's disease: interplay of IL-7/IL-7R signalling and CD132 deficiencyMemorias do Instituto Oswaldo Cruz · 2026Article
- Decreased gene expression of interleukin 2 receptor subunit γ (CD132) in tissues of patients with Crohn's disease.World journal of gastroenterology · 2025Article
- Involvement of the NLRP3/IL-1β pathway in activation and effector functions of γδT17 cells in patients with ulcerative colitis.World journal of gastroenterology · 2025Observational
- Development of Time-Aggregated Machine Learning Model for Relapse Prediction in Pediatric Crohn's Disease.Clinical and translational gastroenterology · 2025Article
- Dietary Zinc Ameliorates TNBS-Induced Colitis in Mice Associated with Regulation of Th1/Th2/Th17 Balance and NF-κB/NLRP3 Signaling Pathway.Biological trace element research · 2024Article
- Article
- Changes in γδT Cells in Peripheral Blood of Patients with Ulcerative Colitis Exacerbations.Archivum immunologiae et therapiae experimentalis · 2021Article
- Age-related changes in lymphocyte subpopulations in healthy Thai children.Journal of clinical laboratory analysis · 2020Article
- Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors.PloS one · 2020Article
- Gammadelta T Cells: Unconventional T Cells Involved in IBD Pathogenesis.Digestive diseases and sciences · 2018Article
- γδ T Cells: Crosstalk Between Microbiota, Chronic Inflammation, and Colorectal Cancer.Frontiers in immunology · 2018Review
- Immunophenotype of Peripheral Blood Lymphocytes in Dogs with Inflammatory Bowel Disease.Journal of veterinary internal medicine · 2017Article
- Determination of Anti-Anisakis Simplex Antibodies and Relationship with αβ and γδ Lymphocyte Subpopulations in Patients with Crohn's Disease.Digestive diseases and sciences · 2017Article
- Current therapy of pediatric Crohn's disease.World journal of gastrointestinal pathophysiology · 2015Review
- Epstein-Barr virus is related with 5-aminosalicylic acid, tonsillectomy, and CD19(+) cells in Crohn's disease.World journal of gastroenterology · 2015Observational
- Quantitative peripheral blood perturbations of γδ T cells in human disease and their clinical implications.Clinical reviews in allergy & immunology · 2014Review
- γδ T Cell-Mediated Immune Responses in Disease and Therapy.Frontiers in immunology · 2014Review
- Article
- Defining the nature of human γδ T cells: a biographical sketch of the highly empathetic.Cellular & molecular immunology · 2013Review
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGammadelta T lymphocytes are an important component of innate immunity. Previous studies have shown their role in the development of Crohn's-like colitis in mice.
aimsThe aim of this study was to measure the γδ T lymphocyte levels in Crohn's disease (CD) patients.
methodsA prospective study of 40 patients with CD compared with 40 healthy subjects (control group) matched by age and sex was undertaken. Lennard-Jones criteria were used for the diagnosis of CD. Disease activity was measured with the Crohn's disease activity index (CDAI). New patients, patients in remission, and patients with active disease were evaluated. Lymphocytic populations of CD3+, CD4+, CD8+, CD56+, CD19+, and αβ and γδ subsets were measured in the peripheral blood of all participants.
resultsThe levels of CD3+, CD4+, CD8+, and CD19+ lymphocytes were decreased in CD patients compared with the control group (P = 0.002, 0.049, 0.003, and 0.023, respectively). Although both γδ and αβ T lymphocytes were lower in patients with CD, γδ T subsets showed the lowest levels in CD patients (mean 0.0259 × 10(9)/l) versus healthy controls (mean 0.0769 × 10(9)/l), P < 0.001. In particular, γδ CD8+ T subsets (mean 0.0068 × 10(9)/l) had the largest difference compared to the control group (mean 0.0199 × 10(9)/l), P = 0.008.
conclusionsThere is a decrease in the global lymphocyte population in the peripheral blood of patients with CD compared to healthy controls. This decrease is more evident in γδ T lymphocytes, especially γδ CD8+ T subsets. Our conclusion is that these results support the theory that a complex alteration of immune responses that affects the total numbers and function of γδ T cells is present in CD.
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