ArticleStem cell reviews and reports2011
Re-assessing K15 as an epidermal stem cell marker.
Article in Stem cell reviews and reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Distinct diversity of skin cell populations of rhinophyma and hypertrophic scar illustrated by scRNA-seq.Frontiers in immunology · 2026Article
- Neural crest precursors from the skin are the primary source of directly reprogrammed neurons.Stem cell reports · 2024Article
- The combined effects of Map3k1 mutation and dioxin on differentiation of keratinocytes derived from mouse embryonic stem cells.Scientific reports · 2022Article
- Alpinetin promotes hair regeneration via activating hair follicle stem cells.Chinese medicine · 2022Article
- Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis.Life science alliance · 2020Article
- Expression of keratin 15 in dentigerous cyst, odontogenic keratocyst and ameloblastoma.Molecular and clinical oncology · 2019Article
- Article
- Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body.Journal of cell science · 2016Article
- Asymmetric stem-cell division ensures sustained keratinocyte hyperproliferation in psoriatic skin lesions.International journal of molecular medicine · 2016Article
- CD271 mediates stem cells to early progeny transition in human epidermis.The Journal of investigative dermatology · 2015Article
- Markers of epidermal stem cell subpopulations in adult mammalian skin.Cold Spring Harbor perspectives in medicine · 2014Review
- Immunohistochemical analyses point to epidermal origin of human Merkel cells.Histochemistry and cell biology · 2014Article
- miR-24 affects hair follicle morphogenesis targeting Tcf-3.Cell death & disease · 2013Article
- Keratin k15 as a biomarker of epidermal stem cells.International journal of molecular sciences · 2013Review
- Epidermal development in mammals: key regulators, signals from beneath, and stem cells.International journal of molecular sciences · 2013Review
- Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling.PloS one · 2012Article
- Epidermal stem cell dynamics.Stem cell research & therapy · 2011Article
- Deregulation of epidermal stem cell niche contributes to pathogenesis of nonhealing venous ulcers.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The intermediate filament keratin 15 (K15) is present in variable amounts in various stratified epithelia, but has also been reported to be a stem cell marker in the hair follicle. Using peptide specific antibodies, we evaluated the temporal and spatial distribution pattern of K15 expression/localization during normal epidermal development and initiation of hair follicle formation, and in the injured mature epidermis (e.g., during acute injury and repair and in tumorigenesis). During development, K15 expression is first localized to a subset of epidermal basal cells and the overlying periderm at E12.5, but its expression is seen throughout the basal layer by E15.5 and beyond. In hair follicle morphogenesis, initial peg formation occurs in a K15-null area at E14.5 and as peg elongation proceeds through to the mature hair follicle, K15 expression follows the leading edge with positive cells restricted to the outer root sheath. In an epidermal injury model, K15 is first up-regulated and associated with both the basal and suprabasal layers of the interfollicular epidermis then expression becomes sporadic and down-regulated before a basal layer-specific association is re-established in the repaired epidermis. During tumorigenesis, K15 is first mis-expressed, and is ultimately down-regulated. Our data suggest that K15 protein expression may reflect not only expression in a stem or progenitor cell subpopulation, but also reflects the activity and responsiveness of basal-like cells to loss of homeostasis of the epidermal differentiation program. Thus, the data suggest caution in using K15 alone to delineate epidermal stem cells, and underscore the need for further investigation of K15 and other markers in epidermal cell subpopulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.