ArticleStem cell reviews and reports2011
Electrically guiding migration of human induced pluripotent stem cells.
Article in Stem cell reviews and reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- Expansion of induced pluripotent stem cells under consideration of bioengineering aspects: part 2.Applied microbiology and biotechnology · 2025Article
- Expansion of induced pluripotent stem cells under consideration of bioengineering aspects: part 1.Applied microbiology and biotechnology · 2025Article
- Bronchial Fibroblasts from Asthmatic Patients Display Impaired Responsiveness to Direct Current Electric Fields (dcEFs).Biomedicines · 2023Article
- Mesenchymal and induced pluripotent stem cell-based therapeutics: a comparison.Applied microbiology and biotechnology · 2023Review
- Stimulation strategies for electrical and magnetic modulation of cells and tissues.Cell regeneration (London, England) · 2023Review
- CD9 negatively regulates collective electrotaxis of the epidermal monolayer by controlling and coordinating the polarization of leader cells.Burns & trauma · 2023Article
- Collagen Matrices Mediate Glioma Cell Migration Induced by an Electrical Signal.Gels (Basel, Switzerland) · 2022Article
- Pulsed Electrical Stimulation Enhances Consistency of Directional Migration of Adipose-Derived Stem Cells.Cells · 2021Article
- EngineeringAPL bioengineering · 2021Article
- Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives.Neuroscience bulletin · 2021Review
- Stimuli-Responsive Biomaterials: Scaffolds for Stem Cell Control.Advanced healthcare materials · 2021Review
- Electrical Stimulation Promotes Stem Cell Neural Differentiation in Tissue Engineering.Stem cells international · 2021Review
- Optimization of Electrical Stimulation for Safe and Effective Guidance of Human Cells.Bioelectricity · 2020Article
- Polarization of ADAM17-driven EGFR signalling in electric field-guided collective migration of epidermal sheets.Journal of cellular and molecular medicine · 2020Article
- Substrate-Dependent Galvanotaxis of Directly Reprogrammed Human Neural Precursor Cells.Bioelectricity · 2020Article
- Controlling properties of human neural progenitor cells using 2D and 3D conductive polymer scaffolds.Scientific reports · 2019Article
- Expression of integrins to control migration direction of electrotaxis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Electrotaxis of Glioblastoma and Medulloblastoma Spheroidal Aggregates.Scientific reports · 2019Article
- Long-Term Potentiation Enhances Neuronal Differentiation in the Chronic Hypoperfusion Model of Rats.Frontiers in aging neuroscience · 2018Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
A major road-block in stem cell therapy is the poor homing and integration of transplanted stem cells with the targeted host tissue. Human induced pluripotent stem (hiPS) cells are considered an excellent alternative to embryonic stem (ES) cells and we tested the feasibility of using small, physiological electric fields (EFs) to guide hiPS cells to their target. Applied EFs stimulated and guided migration of cultured hiPS cells toward the anode, with a stimulation threshold of <30 mV/mm; in three-dimensional (3D) culture hiPS cells remained stationary, whereas in an applied EF they migrated directionally. This is of significance as the therapeutic use of hiPS cells occurs in a 3D environment. EF exposure did not alter expression of the pluripotency markers SSEA-4 and Oct-4 in hiPS cells. We compared EF-directed migration (galvanotaxis) of hiPS cells and hES cells and found that hiPS cells showed greater sensitivity and directedness than those of hES cells in an EF, while hES cells migrated toward cathode. Rho-kinase (ROCK) inhibition, a method to aid expansion and survival of stem cells, significantly increased the motility, but reduced directionality of iPS cells in an EF by 70-80%. Thus, our study has revealed that physiological EF is an effective guidance cue for the migration of hiPS cells in either 2D or 3D environments and that will occur in a ROCK-dependent manner. Our current finding may lead to techniques for applying EFs in vivo to guide migration of transplanted stem cells.
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