Trial reportEuropean journal of applied physiology2011
Effects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacity.
Trial report in European journal of applied physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 79 citations in OpenAlex.
- Trial
- Combined L-carnosine and L-tyrosine supplementation as an ergogenic strategy for physical and cognitive performance under fatigue in professional football players.Frontiers in nutrition · 2026Article
- Effect of histidine and carnosine on haemoglobin recovery in anaemia induced-kidney damage and iron-loading mouse models.Amino acids · 2025Article
- Does Vitamin B6 Act as an Exercise Mimetic in Skeletal Muscle?International journal of molecular sciences · 2024Review
- Protein and Leucine Requirements for Maximal Muscular Development and Athletic Performance Are Achieved with Completely Plant-Based Diets Modeled to Meet Energy Needs in Adult Male Rugby Players.Sports (Basel, Switzerland) · 2024Article
- Article
- Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting.Journal of cachexia, sarcopenia and muscle · 2023Article
- Carnosine increases insulin-stimulated glucose uptake and reduces methylglyoxal-modified proteins in type-2 diabetic human skeletal muscle cells.Amino acids · 2023Article
- Muscular carnosine is a marker for cardiorespiratory fitness and cardiometabolic risk factors in men with type 1 diabetes.European journal of applied physiology · 2022Article
- The Impact of Vegan and Vegetarian Diets on Physical Performance and Molecular Signaling in Skeletal Muscle.Nutrients · 2021Review
- Exercise capacity of vegan, lacto-ovo-vegetarian and omnivorous recreational runners.Journal of the International Society of Sports Nutrition · 2019Article
- Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized?Frontiers in nutrition · 2019Review
- Plant-Based Diets: Considerations for Environmental Impact, Protein Quality, and Exercise Performance.Nutrients · 2018Review
- Exercise alters and β-alanine combined with exercise augments histidyl dipeptide levels and scavenges lipid peroxidation products in human skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women.Nutrients · 2017Article
- Limitations in intense exercise performance of athletes - effect of speed endurance training on ion handling and fatigue development.The Journal of physiology · 2017Review
- Physiological Adaptations to Hypoxic vs. Normoxic Training during Intermittent Living High.Frontiers in physiology · 2017Article
- Cardiorespiratory Fitness and Peak Torque Differences between Vegetarian and Omnivore Endurance Athletes: A Cross-Sectional Study.Nutrients · 2016Article
- Nitrate Intake Promotes Shift in Muscle Fiber Type Composition during Sprint Interval Training in Hypoxia.Frontiers in physiology · 2016Article
- Exercise training and Beta-alanine-induced muscle carnosine loading.Frontiers in nutrition · 2015Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carnosine is an abundant dipeptide in human skeletal muscle with proton buffering capacity. There is controversy as to whether training can increase muscle carnosine and thereby provide a mechanism for increased buffering capacity. This study investigated the effects of 5 weeks sprint training combined with a vegetarian or mixed diet on muscle carnosine, carnosine synthase mRNA expression and muscle buffering capacity. Twenty omnivorous subjects participated in a 5 week sprint training intervention (2-3 times per week). They were randomized into a vegetarian and mixed diet group. Measurements (before and after the intervention period) included carnosine content in soleus, gastrocnemius lateralis and tibialis anterior by proton magnetic resonance spectroscopy ((1)H-MRS), true-cut biopsy of the gastrocnemius lateralis to determine in vitro non-bicarbonate muscle buffering capacity, carnosine content (HPLC method) and carnosine synthase (CARNS) mRNA expression and 6 × 6 s repeated sprint ability (RSA) test. There was a significant diet × training interaction in soleus carnosine content, which was non-significantly increased (+11%) with mixed diet and non-significantly decreased (-9%) with vegetarian diet. Carnosine content in other muscles and gastrocnemius buffer capacity were not influenced by training. CARNS mRNA expression was independent of training, but decreased significantly in the vegetarian group. The performance during the RSA test improved by training, without difference between groups. We found a positive correlation (r = 0.517; p = 0.002) between an invasive and non-invasive method for muscle carnosine quantification. In conclusion, this study shows that 5 weeks sprint training has no effect on the muscle carnosine content and carnosine synthase mRNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.