ArticlePflugers Archiv : European journal of physiology2011
Membrane cholesterol modulates cochlear electromechanics.
Article in Pflugers Archiv : European journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of Cholesterol Modulation on Cisplatin-Induced Hearing Loss.bioRxiv : the preprint server for biology · 2025Article
- The sensitivity of mechanoelectrical transduction response phase to acoustic overstimulation is calcium-dependent.Pflugers Archiv : European journal of physiology · 2024Article
- LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging.PLoS biology · 2023Article
- The summating potential polarity encodes the ear health condition.Cellular and molecular life sciences : CMLS · 2023Article
- Spatiotemporal Developmental Upregulation of Prestin Correlates With the Severity and Location of Cyclodextrin-Induced Outer Hair Cell Loss and Hearing Loss.Frontiers in cell and developmental biology · 2021Article
- Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension.Journal of lipid research · 2021Article
- Article
- The chloride-channel blocker 9-anthracenecarboxylic acid reduces the nonlinear capacitance of prestin-associated charge movement.The European journal of neuroscience · 2016Article
- Susceptibility of outer hair cells to cholesterol chelator 2-hydroxypropyl-β-cyclodextrine is prestin-dependent.Scientific reports · 2016Article
- Hearing Loss and Otopathology Following Systemic and Intracerebroventricular Delivery of 2-Hydroxypropyl-Beta-Cyclodextrin.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
- Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins.PLoS genetics · 2015Article
- Effects of salicylate on sound-evoked outer hair cell stereocilia deflections.Pflugers Archiv : European journal of physiology · 2015Article
- Basilar membrane and tectorial membrane stiffness in the CBA/CaJ mouse.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Localization and proteomic characterization of cholesterol-rich membrane microdomains in the inner ear.Journal of proteomics · 2014Article
- Non-uniform distribution of outer hair cell transmembrane potential induced by extracellular electric field.Biophysical journal · 2013Article
- Effects of cholesterol alterations are mediated via G-protein-related pathways in outer hair cells.Pflugers Archiv : European journal of physiology · 2013Article
- Noise-induced alterations in cochlear mechanics, electromotility, and cochlear amplification.Pflugers Archiv : European journal of physiology · 2013Article
- Microdomains shift and rotate in the lateral wall of cochlear outer hair cells.Biophysical journal · 2013Article
- Membrane cholesterol strongly influences confined diffusion of prestin.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Changing the concentration of cholesterol in the plasma membrane of isolated outer hair cells modulates electromotility and prestin-associated charge movement, suggesting that a similar manipulation would alter cochlear mechanics. We examined cochlear function before and after depletion of membrane cholesterol with methyl-β-cyclodextrin (MβCD) in an excised guinea pig temporal bone preparation. The mechanical response of the cochlear partition to acoustic and/or electrical stimulation was monitored using laser interferometry and time-resolved confocal microscopy. The electromechanical response in untreated preparations was asymmetric with greater displacements in response to positive currents. Exposure to MβCD increased the magnitude and asymmetry of the response, without changing the frequency tuning of sound-evoked mechanical responses or cochlear microphonic potentials. Sodium salicylate reversibly blocked the enhanced electromechanical response in cholesterol depleted preparations. The increase of sound-evoked vibrations during positive current injection was enhanced following MβCD in some preparations. Imaging was used to assess cellular integrity which remained unchanged after several hours of exposure to MβCD in several preparations. The enhanced electromechanical response reflects an increase in outer hair cell electromotility and may reveal features of cholesterol distribution and trafficking in outer hair cells.
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