ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2011
Isolation, characterization and quantification of tricin and flavonolignans in the medicinal rice Njavara (Oryza sativa L.), as compared to staple varieties.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 66 citations in OpenAlex.
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- Chemical Structure Diversity and Extensive Biological Functions of Specialized Metabolites in Rice.International journal of molecular sciences · 2023Review
- Phytochemical profile and anti-inflammatory activity of the hull of γ-irradiated wheat mutant lines (Frontiers in nutrition · 2023Article
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- Isolation of Tricin as a Xanthine Oxidase Inhibitor from Sweet White Clover (Molecules (Basel, Switzerland) · 2018Article
- Enzyme and high pressure assisted extraction of tricin from rice hull and biological activities of rice hull extract.Food science and biotechnology · 2016Article
- Metabolome-genome-wide association study dissects genetic architecture for generating natural variation in rice secondary metabolism.The Plant journal : for cell and molecular biology · 2015Article
- Cytochrome P450 93G1 Is a Flavone Synthase II That Channels Flavanones to the Biosynthesis of Tricin O-Linked Conjugates in Rice.Plant physiology · 2014Article
- Tricin 4'-O-(erythro-β-guaiacylglyceryl) ether and tricin 4'-O-(threo-β-guaiacylglyceryl) ether isolated from Njavara (Oryza sativa L. var. Njavara), induce apoptosis in multiple tumor cells by mitochondrial pathway.Journal of natural medicines · 2013Article
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5 authors at 2 institutions in 1 country.
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Abstract
Njavara is an important medicinal rice variety of Kerala, India, widely used in Ayurveda as a 'health food' and in the treatment of rheumatoid arthritis, paralysis, neurodegenerative diseases and in rejuvenation therapy. Phytochemical investigations and spectroscopic studies of the diethyl ether fraction of methanolic extract of Njavara Black (NB) rice bran gave three important compounds namely, tricin and two rare flavonolignans- tricin 4'-O-(erythro-β-guaiacylglyceryl) ether and tricin 4'-O-(threo-β-guaiacylglyceryl) ether. The EC(50) values of these compounds in DPPH system were 90.39, 352.04 and 208.1 μg/ml, respectively. Quantification of the compounds by HPLC in NB and staple, non-medicinal rice varieties Sujatha (SJ) and Palakkadan Matta (PM) showed that tricin is present 39.64 and 16.12 fold higher in NB, compared to SJ and PM, respectively. This is the first report on the occurrence of tricin at significantly higher levels in Njavara and occurrence of the two flavonolignans in Oryza sativa species. Of the three compounds, tricin and the threo- form of flavonolignan showed anti-inflammatory effect of >65% after 5 h, at 2 mg/kg, in carrageenan-induced, paw edema experiments in rats. The results of the study corroborate with the preferential use of Njavara in indigenous medicine, over staple varieties.
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