ArticleInternational journal of emergency medicine2010
Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen.
Article in International journal of emergency medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis report describes two cases with unexplained positive results for phencyclidine (PCP).
aimsThis case will correlate lamotrigine (Lamictal®) use with false-positive results for PCP on a rapid urine toxicology screen.
methodsCase 1: A 62-year-old male arrived to the emergency department in extreme psychosis. All positive results on the urine drug screen could be accounted for except PCP. A comprehensive drug screen was performed to confirm PCP use, but returned negative. PCP was ruled out as the causative agent. The reason for the PCP false positive remained unknown. Case 2: A 49-year-old female presented to the ED with a history of seizures and depression. Despite positive PCP results on a rapid urine drug screen, PCP use was ruled out due to patient presentation and comprehensive history.
resultsThe differential diagnosis in case 1 included PCP abuse until PCP was ruled out by a comprehensive drug screen. A literature search failed to explain a reason for false-positive results. The patient in case 2 was not psychotic, but returned a positive urinalysis result for PCP. Case 2's presentation combined with a comprehensive history at the facility ruled out PCP use. Both patients were taking the anti-seizure medication lamotrigine with nothing else in common.
conclusionLamotrigine has the potential to cause false-positive results for PCP on the Bio-Rad TOX/See urine toxicology screen.
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