Evidence map›Paper›PMID 21373264›Full record

ArticleJournal of clinical biochemistry and nutrition2011

Ghrelin and oxidative stress in gastrointestinal tract.

Hidekazu Suzuki, Juntaro Matsuzaki, Toshifumi Hibi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Potentiality of ghrelin as antioxidant and protective agent.Redox report : communications in free radical research · 2021
    Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Endocrinopathies and Male Infertility.Life (Basel, Switzerland) · 2021
    Review
  7. Review
  8. Gut peptides and the microbiome: focus on ghrelin.Current opinion in endocrinology, diabetes, and obesity · 2021
    Review
  9. Review
  10. Review
  11. Article
  12. Ghrelin as an Anti-Sepsis Peptide: Review.Frontiers in immunology · 2020
    Review
  13. Article
  14. Eradication therapy forJournal of clinical biochemistry and nutrition · 2019
    Article
  15. Reactive oxygen species and male reproductive hormones.Reproductive biology and endocrinology : RB&E · 2018
    Review
  16. Review
  17. Introduction to serial reviews: Oxidative stress and digestive diseases.Journal of clinical biochemistry and nutrition · 2018
    Review
  18. Article
  19. World journal of gastroenterology · 2018
    Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hidekazu SuzukiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Juntaro Matsuzaki
Toshifumi Hibi
Keio University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is a major cause of the gastrointestinal damage under physical or psychological stress. Ghrelin exhibits gastroprotective effects and they are supposed to be derived from antioxidant effects. In gastroduodenal mucosal injury, the plasma ghrelin levels increase in response to the demand for gastroduodenal cytoprotection. However, in the condition of Helicobacter pylori-induced gastric mucosal severe atrophy, the plasma ghrelin concentration shifted to lower levels. In diabetic gastroparesis, the regulation of ghrelin secretion is impaired with vagal nerve dysfunction. Selective ghrelin agonist is expected to represent a new class of prokinetic agent. In addition, the plasma ghrelin levels are also enhanced by systemic oxidative stress, and ghrelin exhibits antioxidant effects in many organs, such as heart, pancreas, and lung. This suggests that ghrelin would be an important player as a sensor of systemic oxidative stress.

Indexed as

gastroparesisghrelinoxidative stresspeptic ulcer

Identifiers

PMID21373264
PMCPMC3045684
OpenAlexW2158765545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.