ArticlePloS one2011
Lack of infection with XMRV or other MLV-related viruses in blood, post-mortem brains and paternal gametes of autistic individuals.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- A Novel Pathogen of an Emerging Infectious Disease (Large Kidney Disease) in Farmed Blue Foxes.Transboundary and emerging diseases · 2023Article
- Infections in children with autism spectrum disorder: Study to Explore Early Development (SEED).Autism research : official journal of the International Society for Autism Research · 2019Article
- No Evidence of Antibodies against GAD65 and Other Specific Antigens in Children with Autism.BBA clinical · 2015Article
- Infection of Xenotransplanted Human Cell Lines by Murine Retroviruses: A Lesson Brought Back to Light by XMRV.Frontiers in oncology · 2013Article
- Utilization of replication-competent XMRV reporter-viruses reveals severe viral restriction in primary human cells.PloS one · 2013Article
- Recombinant origin, contamination, and de-discovery of XMRV.Current opinion in virology · 2012Review
- Perinatal stress, brain inflammation and risk of autism-review and proposal.BMC pediatrics · 2012Review
- Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques.Journal of virology · 2012Article
- XMRV and prostate cancer--a 'final' perspective.Nature reviews. Urology · 2012Review
- Article
- Detection of murine leukemia virus or mouse DNA in commercial RT-PCR reagents and human DNAs.PloS one · 2011Article
- No evidence of murine leukemia virus-related viruses in live attenuated human vaccines.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutistic spectrum disorder (ASD) is characterized by impaired language, communication and social skills, as well as by repetitive and stereotypic patterns of behavior. Many autistic subjects display a dysregulation of the immune system which is compatible with an unresolved viral infection with prenatal onset, potentially due to vertical viral transmission. Recently, the xenotropic murine leukemia virus-related virus (XMRV) has been implicated in chronic fatigue syndrome (CFS) and in prostate cancer by several, though not all studies. METHODOLOGY/PRINCIPAL
findingsWe assessed whether XMRV or other murine leukemia virus (MLV)-related viruses are involved in autistic disorder. Using nested PCR targeted to gag genomic sequences, we screened DNA samples from: (i) peripheral blood of 102 ASD patients and 97 controls, (ii) post-mortem brain samples of 20 ASD patients and 17 sex- and age-matched controls, (iii) semen samples of 11 fathers of ASD children, 25 infertile individuals and 7 fertile controls. No XMRV gag DNA sequences were detected, whereas peripheral blood samples of 3/97 (3.1%) controls were positive for MLV. CONCLUSIONS| SIGNIFICANCE: No MLV-related virus was detected in blood, brain, and semen samples of ASD patients or fathers. Hence infection with XMRV or other MLV-related viruses is unlikely to contribute to autism pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.