Evidence map›Paper›PMID 21372323›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2011

Eukaryote-like serine/threonine kinases and phosphatases in bacteria.

Sandro F F Pereira, Lindsie Goss, Jonathan Dworkin

Abstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 367 citations in OpenAlex.

  1. Review
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  8. Interaction of themBio · 2025
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139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sandro F F PereiraDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Lindsie Goss
Jonathan Dworkin
Columbia University · US

Funding

UPR--MEDICAL SCIENCES CAMPUS, MBRS PROGRAMS06GM008224 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI SILVA, WALTER I · 1989 to 2008
$28.0M
Peptidoglycan synthesis during sporulationR01GM081368 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DWORKIN, JONATHAN · 2008 to 2012
$1.6M
NIGMS NIH HHS GM008224-22NIGMS NIH HHS GM081368-02NIGMS NIH HHS R01 GM081368NIGMS NIH HHS S06 GM008224
6 · The paper itself

Abstract

Genomic studies have revealed the presence of Ser/Thr kinases and phosphatases in many bacterial species, although their physiological roles have largely been unclear. Here we review bacterial Ser/Thr kinases (eSTKs) that show homology in their catalytic domains to eukaryotic Ser/Thr kinases and their partner phosphatases (eSTPs) that are homologous to eukaryotic phosphatases. We first discuss insights into the enzymatic mechanism of eSTK activation derived from structural studies on both the ligand-binding and catalytic domains. We then turn our attention to the identified substrates of eSTKs and eSTPs for a number of species and to the implications of these findings for understanding their physiological roles in these organisms.

Indexed as

Phosphoric Monoester HydrolasesProtein Serine-Threonine KinasesSequence Homology, Amino AcidAmino Acid SequenceBacteriaBacterial ProteinsCatalytic DomainEukaryotaModels, MolecularMolecular Sequence DataPhosphorylationStructure-Activity RelationshipBacterial ProteinsPhosphoric Monoester HydrolasesProtein Serine-Threonine Kinases

Identifiers

PMID21372323
PMCPMC3063355
OpenAlexW2127359880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.