ArticleArteriosclerosis, thrombosis, and vascular biology2011
Macrophage-derived tumor necrosis factor-alpha is an early component of the molecular cascade leading to angiogenesis in response to aortic injury.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 48 citations in OpenAlex.
- Beyond immunity: macrophage plasticity in vascular regeneration.npj biomedical innovations · 2026Review
- Serum-Free Mouse Aortic Ring Assay of Angiogenesis.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Dynamic Roles and Expanding Diversity of Adipose Tissue Macrophages in Obesity.Journal of obesity & metabolic syndrome · 2024Review
- Unraveling the complex roles of macrophages in obese adipose tissue: an overview.Frontiers of medicine · 2024Review
- VEGF signaling: Role in angiogenesis and beyond.Biochimica et biophysica acta. Reviews on cancer · 2024Review
- Ifi30 Is Required for Sprouting Angiogenesis During Caudal Vein Plexus Formation in Zebrafish.Frontiers in physiology · 2022Article
- TNFα-Induced LDL Cholesterol Accumulation Involve Elevated LDLR Cell Surface Levels and SR-B1 Downregulation in Human Arterial Endothelial Cells.International journal of molecular sciences · 2021Article
- Endothelial cell and T-cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation.British journal of pharmacology · 2021Review
- Adventitial Progenitor Cells of Human Great Saphenous Vein Enhance the Resolution of Venous Thrombosis via Neovascularization.Stem cells international · 2021Article
- RecombinantPharmaceutics · 2020Article
- Article
- Myeloid SOCS3 Deficiency Regulates Angiogenesis via Enhanced Apoptotic Endothelial Cell Engulfment.Journal of innate immunity · 2020Article
- The plaque-aortic ring assay: a new method to study human atherosclerosis-induced angiogenesis.Angiogenesis · 2019Article
- Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue.Stem cells international · 2019Article
- Properties and functions of adipose tissue macrophages in obesity.Immunology · 2018Review
- IL-17 in neonatal health and disease.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Review
- Article
- Bone regeneration is associated with the concentration of tumour necrosis factor-α induced by sericin released from a silk mat.Scientific reports · 2017Article
- Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury.Biomaterials · 2017Article
- Identification of different macrophage subpopulations with distinct activities in a mouse model of oxygen-induced retinopathy.International journal of molecular medicine · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe goal of this study was to define the role of tumor necrosis factor-α (TNFα) in the cascade of gene activation that regulates aortic angiogenesis in response to injury. METHODS AND
resultsAngiogenesis was studied by culturing rat or mouse aortic rings in collagen gels. Gene expression was evaluated by quantitative reverse transcription-polymerase chain reaction, microarray analysis, immunocytochemistry, and ELISA. TNFα gene disruption and recombinant TNFα or blocking antibodies against vascular endothelial growth factor (VEGF) or TNF receptors were used to investigate TNFα-mediated angiogenic mechanisms. Resident aortic macrophages were depleted with liposomal clodronate. Angiogenesis was preceded by overexpression of TNFα and TNFα-inducible genes. Studies with isolated cells showed that macrophages were the main source of TNFα. Angiogenesis, VEGF production, and macrophage outgrowth were impaired by TNFα gene disruption and promoted by exogenous TNFα. Antibody-mediated inhibition of TNF receptor 1 significantly inhibited angiogenesis. The proangiogenic effect of TNFα was suppressed by blocking VEGF or by ablating aortic macrophages. Exogenous TNFα, however, maintained a limited proangiogenic capacity in the absence of macrophages and macrophage-mediated VEGF production.
conclusionsOverexpression of TNFα is required for optimal VEGF production and angiogenesis in response to injury. This TNFα/VEGF-mediated angiogenic pathway requires macrophages. The residual capacity of TNFα to stimulate angiogenesis in macrophage-depleted aortic cultures implies the existence of a VEGF-independent alternate pathway of TNFα-induced angiogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.