ArticleThe Journal of biological chemistry2011
Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats.The EMBO journal · 2023Article
- Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle.Scientific reports · 2023Article
- Selenium Deficiency Is Associated with Pro-longevity Mechanisms.Cell reports · 2019Article
- The Naked Mole Rat: A Unique Example of Positive Oxidative Stress.Oxidative medicine and cellular longevity · 2019Review
- Amblyomma maculatum SECIS binding protein 2 and putative selenoprotein P are indispensable for pathogen replication and tick fecundity.Insect biochemistry and molecular biology · 2017Article
- Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.Physiological reviews · 2016Review
- Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity.Cell reports · 2015Article
- Selenoproteins and cardiovascular stress.Thrombosis and haemostasis · 2015Review
- Article
- Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.Cell reports · 2014Article
- Comparative genetics of longevity and cancer: insights from long-lived rodents.Nature reviews. Genetics · 2014Review
- Selenoproteins: molecular pathways and physiological roles.Physiological reviews · 2014Review
- The naked mole-rat response to oxidative stress: just deal with it.Antioxidants & redox signaling · 2013Review
- Investigation of anti-cancer mechanisms by comparative analysis of naked mole rat and rat.BMC systems biology · 2013Article
- Friend or foe? The current epidemiologic evidence on selenium and human cancer risk.Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2013Review
- High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3.Antioxidants & redox signaling · 2012Article
- Article
- Article
- Genome Stability Maintenance in Naked Mole-Rat.Acta naturaeArticle
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
Naked mole rat (MR) Heterocephalus glaber is a rodent model of delayed aging because of its unusually long life span (>28 years). It is also not known to develop cancer. In the current work, tissue imaging by x-ray fluorescence microscopy and direct analyses of trace elements revealed low levels of selenium in the MR liver and kidney, whereas MR and mouse brains had similar selenium levels. This effect was not explained by uniform selenium deficiency because methionine sulfoxide reductase activities were similar in mice and MR. However, glutathione peroxidase activity was an order of magnitude lower in MR liver and kidney than in mouse tissues. In addition, metabolic labeling of MR cells with (75)Se revealed a loss of the abundant glutathione peroxidase 1 (GPx1) band, whereas other selenoproteins were preserved. To characterize the MR selenoproteome, we sequenced its liver transcriptome. Gene reconstruction revealed standard selenoprotein sequences except for GPx1, which had an early stop codon, and SelP, which had low selenocysteine content. When expressed in HEK 293 cells, MR GPx1 was present in low levels, and its expression could be rescued neither by removing the early stop codon nor by replacing its SECIS element. In addition, GPx1 mRNA was present in lower levels in MR liver than in mouse liver. To determine if GPx1 deficiency could account for the reduced selenium content, we analyzed GPx1 knock-out mice and found reduced selenium levels in their livers and kidneys. Thus, MR is characterized by the reduced utilization of selenium due to a specific defect in GPx1 expression.
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