ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Diaphragm long-term facilitation following acute intermittent hypoxia during wakefulness and sleep.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Single-session effects of acute intermittent hypoxia on breathing function after human spinal cord injury.Experimental neurology · 2021Trial
- Long-term facilitation of ventilation in humans with chronic spinal cord injury.American journal of respiratory and critical care medicine · 2014Trial
- Diurnal cycle and acute intermittent hypoxia protocol interact to regulate ventilatory long-term facilitation in unanesthetized rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Identification of eupneic breathing using machine learning.Journal of neurophysiology · 2024Article
- Effects of C2 hemisection on respiratory and cardiovascular functions in rats.Neural regeneration research · 2023Article
- Magnitude and Mechanism of Phrenic Long-term Facilitation Shift Between Daily Rest Versus Active Phase.Function (Oxford, England) · 2023Article
- Dose-dependent phosphorylation of endogenous Tau by intermittent hypoxia in rat brain.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Breathing in Duchenne muscular dystrophy: translation to therapy.The Journal of physiology · 2022Review
- Automated evaluation of respiratory signals to provide insight into respiratory drive.Respiratory physiology & neurobiology · 2022Article
- High frequency repetitive Transcranial Magnetic Stimulation promotes long lasting phrenic motoneuron excitability via GABAergic networks.Respiratory physiology & neurobiology · 2021Article
- Divergent receptor utilization is necessary for phrenic long-term facilitation over the course of motor neuron loss following CTB-SAP intrapleural injections.Journal of neurophysiology · 2021Article
- Effect of acute intermittent hypoxia on cortico-diaphragmatic conduction in healthy humans.Experimental neurology · 2021Article
- Baseline Arterial COFrontiers in physiology · 2021Article
- Applications of a novel radiotelemetry method for the measurement of intrathoracic pressures and physiological rhythms in freely behaving mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Effect of acute intermittent hypoxia treatment on ventilatory load compensation and magnitude estimation of inspiratory resistive loads in an individual with chronic incomplete cervical spinal cord injury.The journal of spinal cord medicine · 2016Review
- Intermittent hypoxia and neurorehabilitation.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Review
- Repetitive acute intermittent hypoxia does not promote generalized inflammatory gene expression in the rat CNS.Respiratory physiology & neurobiology · 2015Article
- Daily acute intermittent hypoxia elicits functional recovery of diaphragm and inspiratory intercostal muscle activity after acute cervical spinal injury.Experimental neurology · 2015Article
- Adenosine 2A receptor inhibition enhances intermittent hypoxia-induced diaphragm but not intercostal long-term facilitation.Journal of neurotrauma · 2014Article
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2 authors at 1 institution in 1 country.
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Abstract
Acute intermittent hypoxia (AIH) elicits a form of respiratory plasticity known as long-term facilitation (LTF). Here, we tested four hypotheses in unanesthetized, spontaneously breathing rats using radiotelemetry for EEG and diaphragm electromyography (Dia EMG) activity: 1) AIH induces LTF in Dia EMG activity; 2) diaphragm LTF (Dia LTF) is more robust during sleep vs. wakefulness; 3) AIH (or repetitive AIH) disrupts natural sleep-wake architecture; and 4) preconditioning with daily AIH (dAIH) for 7 days enhances Dia LTF. Sleep-wake states and Dia EMG were monitored before (60 min), during, and after (60 min) AIH (10, 5-min hypoxic episodes, 5-min normoxic intervals; n = 9), time control (continuous normoxia, n = 8), and AIH following dAIH preconditioning for 7 days (n = 7). Dia EMG activities during quiet wakefulness (QW), rapid eye movement (REM), and non-REM (NREM) sleep were analyzed and normalized to pre-AIH values in the same state. During NREM sleep, diaphragm amplitude (25.1 ± 4.6%), frequency (16.4 ± 4.7%), and minute diaphragm activity (amplitude × frequency; 45.2 ± 6.6%) increased above baseline 0-60 min post-AIH (all P < 0.05). This Dia LTF was less robust during QW and insignificant during REM sleep. dAIH preconditioning had no effect on LTF (P > 0.05). We conclude that 1) AIH induces Dia LTF during NREM sleep and wakefulness; 2) Dia LTF is greater in NREM sleep vs. QW and is abolished during REM sleep; 3) AIH and repetitive AIH disrupt natural sleep patterns; and 4) Dia LTF is unaffected by dAIH. The capacity for plasticity in spinal pump muscles during sleep and wakefulness suggests an important role in the neural control of breathing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.