ArticleNeuro-oncology2011
Pretreatment neuropsychological deficits in children with brain tumors.
Article in Neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- "Chemobrain" in childhood cancer survivors-the impact on social, academic, and daily living skills: a qualitative systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- Working memory training in pediatric brain tumor survivors after recent diagnosis: Challenges and initial effects.Applied neuropsychology. ChildTrial
- Review
- Changes on Cognition and Brain Network Temporal Variability After Pediatric Neurosurgery.Neurosurgery · 2025Article
- Structural and functional alterations in the contralateral hemisphere following pediatric intracranial surgery: a pilot longitudinal neuroimaging study.Frontiers in human neuroscience · 2025Article
- The Role of the Cerebellum in Advanced Cognitive Processes in Children.Biomedicines · 2024Review
- Exploring tumor-related language disorders: Pretreatment and post-treatment considerations.Asia-Pacific journal of oncology nursing · 2024Article
- Impact of socioeconomic status and chemotherapy on neurocognitive performance in children with brain tumors.Neuro-oncology practice · 2023Article
- Neurocognitive and Psychological Outcomes among Children and Adolescents with Brain Tumors: Development of an Observational and Longitudinal Prospective Study Protocol.Behavioral sciences (Basel, Switzerland) · 2023Article
- Functional Alteration in the Brain Due to Tumour Invasion in Paediatric Patients: A Systematic Review.Cancers · 2023Review
- Tumor region associated with specific processing speed outcomes.Pediatric blood & cancer · 2023Article
- Predicting neurocognitive function in pediatric brain tumor early survivorship: The neurological predictor scale and the incremental validity of tumor size.Pediatric blood & cancer · 2022Article
- Long-term neuropsychological outcomes of survivors of young childhood brain tumors treated on the Head Start II protocol.Neuro-oncology practice · 2021Article
- Neurotoxic Effects of Childhood Cancer Therapy and Its Potential Neurocognitive Impact.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Linguistic-Cognitive Outcomes in Children with Acute Lymphoid Leukemia: An Exploratory Study.Journal of multidisciplinary healthcare · 2021Article
- Cerebellar mutism syndrome: current approaches to minimize risk for CMS.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Effects of supratentorial and infratentorial tumor location on cognitive functioning of children with brain tumor.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Temozolomide and oral etoposide in children with recurrent malignant brain tumors.Drugs in context · 2020Review
- Guidelines for Treatment and Monitoring of Adult Survivors of Pediatric Brain Tumors.Current treatment options in oncology · 2019Review
- Cognitive functioning of pediatric patients with brain tumor: an investigation of the role of gender.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Observational
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment of childhood brain cancer has been associated with long-term cognitive morbidity in children. In the present study, the cognitive status of children with brain tumors was examined prior to any treatment to single out the role of tumor and tumor-related factors in cognitive deficits. Eighty-three children with newly diagnosed brain tumors (mean age, 8.6 years; range, 7 months to 16.6 years; median, 9.4 years) completed an extensive battery of age-related tests to assess cognitive function before any therapeutic intervention. Magnetic resonance imaging (MRI) was used to determine tumor site and volume and tumor-related factors. Performance under test was compared with symptom duration, neurological status, epilepsy, and MRI. Cognitive difficulties are detected at diagnosis in as many as 50% of patients for some cognitive domains; 6% of patients present with true-diagnosed mental retardation. The location of the tumor is the principal determinant of cognitive deficits, with major impairment in children with cortical tumors. Symptom duration and the presence of epilepsy are significantly associated with neuropsychological disabilities, while neuroradiological tumor-related variables do not correlate clearly with neurocognitive performance. The knowledge of the pre-existing cognitive deficits is critical to evaluate the results of treatment, providing a baseline for assessing the true impact of therapy in determining cognitive decline. In addition, the study suggests that some clinical variables require careful monitoring, because they could be specifically implicated in the neuropsychological outcome; the efforts to reduce the impact of these factors could ameliorate long-term prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.