ArticleInvestigative ophthalmology & visual science2011
Very late antigen-1 mediates corneal lymphangiogenesis.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Lymphangiogenesis Guidance Mechanisms and Therapeutic Implications in Pathological States of the Cornea.Cells · 2023Review
- Aqueous humor induces lymphatic regression on the ocular surface.The ocular surface · 2020Article
- Variable Responses to Corneal Grafts: Insights from Immunology and Systems Biology.Journal of clinical medicine · 2020Review
- TGFBIp mediates lymphatic sprouting in corneal lymphangiogenesis.Journal of cellular and molecular medicine · 2019Article
- Lymphangiogenesis guidance by paracrine and pericellular factors.Genes & development · 2017Review
- Alloimmunity and Tolerance in Corneal Transplantation.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Intravital Imaging Reveals Dynamics of Lymphangiogenesis and Valvulogenesis.Scientific reports · 2016Article
- MicroRNA-184 Regulates Corneal Lymphangiogenesis.Investigative ophthalmology & visual science · 2015Article
- Integrin Alpha-9 Mediates Lymphatic Valve Formation in Corneal Lymphangiogenesis.Investigative ophthalmology & visual science · 2015Article
- Role of angiopoietin-2 in corneal lymphangiogenesis.Investigative ophthalmology & visual science · 2014Article
- Corneal lymphatic valve formation in relation to lymphangiogenesis.Investigative ophthalmology & visual science · 2014Article
- Article
- Conjunctival lymphatic response to corneal inflammation in mice.Journal of ophthalmology · 2012Article
- Integrins and their extracellular matrix ligands in lymphangiogenesis and lymph node metastasis.International journal of cell biology · 2012Article
- Live imaging of newly formed lymphatic vessels in the cornea.Cell research · 2011Article
- Combined blockade of VEGFR-3 and VLA-1 markedly promotes high-risk corneal transplant survival.Investigative ophthalmology & visual science · 2011Article
- Article
- Increased lymphangiogenesis and hemangiogenesis in infant cornea.Lymphatic research and biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the specific role of very late antigen-1 (VLA-1; also known as integrin α1β1) in corneal inflammatory lymphangiogenesis in vivo and lymphatic endothelial cell functions in vitro.
methodsA standard suture-induced corneal inflammatory lymphangiogenesis model was used in normal adult BALB/c mice to test the effect of systemic administration of VLA-1-neutralizing antibody on lymphatic formation and macrophage infiltration in vivo. Additionally, a human lymphatic endothelial cell culture system was used to examine the effect of VLA-1 gene depletion on lymphatic endothelial cell functions in vitro using small interfering RNAs.
resultsThese data demonstrated, for the first time, that VLA-1 blockade significantly suppressed corneal lymphangiogenesis and macrophage infiltration during inflammation. Moreover, VLA-1 gene depletion led to a marked inhibition of lymphatic endothelial cell processes of adhesion, proliferation, and capillary tube formation.
conclusionsThese novel findings together indicate that VLA-1 is critically involved in the processes of lymphangiogenesis. Further investigation on this factor may provide novel therapies for corneal inflammation, transplant rejection, and other lymphatic-related disorders in the body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.