ArticleInvestigative ophthalmology & visual science2011
Postnatal changes in the developing rat extraocular muscles.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Developmental, Physiological and Phylogenetic Perspectives on the Expression and Regulation of Myosin Heavy Chains in Craniofacial Muscles.International journal of molecular sciences · 2024Review
- Increasing Muscle Speed Drives Changes in the Neuromuscular Transform of Motor Commands during Postnatal Development in Songbirds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Fundamental constraints in synchronous muscle limit superfast motor control in vertebrates.eLife · 2017Article
- Development transitions of thin filament proteins in rat extraocular muscles.Experimental cell research · 2013Article
- Nonclassical innervation patterns in mammalian extraocular muscles.Current eye research · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo examine the distribution and timing of expression of nonmuscle myosin IIB (nmMyH IIB) and the extraocular muscle (EOM)-specific myosin (EO-MyHC) during postnatal development of the rat extraocular muscles.
methodsWhole orbits were collected from postnatal development day (P) 1 through P30 from Sprague-Dawley rats. Samples were analyzed by immunofluorescence microscopy and Western blot to examine the distribution and abundance of nmMyH IIB and EO-MyHC compared with other myosin isoforms and sarcomeric α-actinin. Polyclonal antibodies were produced to specifically detect EO-MyHC. Postnatal limb muscles were used as control.
resultsAnalysis of EOM morphology in the developing orbits indicates that the global and orbital layers are not evident until day P15. The distribution of nmMyH IIB changes between days P10 and P15 from a subsarcolemma distribution to an intrafiber distribution in the global layer. EO-MyHC appears by day p15, primarily in the orbital layer of the EOMs. Sarcomeric α-actinin was equally abundant in the EOMs at all stages. Fetal MyHC was the predominant isoform at day P1 but slowly diminished in abundance with age in a layer-specific manner.
conclusionsThese data demonstrate that significant changes occur in the EOMs from P10 to P15 and suggest that visual stimulation may play a role in the signals that regulate both nmMyH IIB and EO-MyHC developmental transitions. The pronounced distinctions of the orbital and global layers occurring by P15 establish the adult morphologic phenotype of the muscle.
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