Evidence map›Paper›PMID 21371511›Full record

ReviewAdvanced drug delivery reviews2011

Induced pluripotent stem cells for regenerative cardiovascular therapies and biomedical discovery.

Ali Nsair, W Robb MacLellan

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Engineering approaches for cardiac organoid formation and their characterization.Translational research : the journal of laboratory and clinical medicine · 2022
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ali NsairDepartment of Medicine, Cardiovascular Research Laboratories and Eli Broad Center for Regenerative Medicine and Stem Cell Research,David Geffen School of Medicine at UCLA, United States
W Robb MacLellan

Funding

ROLE OF P38 MAPK AND PP2C IN ISCHEMIC INJURY AND PROTECTIONP01HL080111 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEISS, JAMES N · 2005 to 2009
$11.6M
Genetic Dissection of Cardiac Growth: The Role of c-MycR01HL070748 · NHLBI · UNIVERSITY OF WASHINGTON · PI MACLELLAN, WILLIAM ROBB · 2004 to 2020
$5.0M
Cardiovascular and Therapeutic Potential of Reprogrammed Human FibroblastsR21HL094941 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACLELLAN, WILLIAM ROBB · 2009 to 2010
$424k
NHLBI NIH HHS HL080111NHLBI NIH HHS HL094941NHLBI NIH HHS P01 HL080111NHLBI NIH HHS R01 HL070748NHLBI NIH HHS R21 HL094941
6 · The paper itself

Abstract

The discovery of induced pluripotent stem cells (iPSC) has, in the short time since their discovery, revolutionized the field of stem cell biology. This technology allows the generation of a virtually unlimited supply of cells with pluripotent potential similar to that of embryonic stem cells (ESC). However, in contrast to ESC, iPSC are not subject to the same ethical concerns and can be easily generated from living individuals. For the first time, patient-specific iPSC can be generated and offer a supply of genetically identical cells that can be differentiated into all somatic cell types for potential use in regenerative therapies or drug screening and testing. As the techniques for generation of iPSC lines are constantly evolving, new uses for human iPSC are emerging from in-vitro disease modeling to high throughput drug discovery and screening. This technology promises to revolutionize the field of medicine and offers new hope for understanding and treatment of numerous diseases.

Indexed as

AnimalsCardiovascular DiseasesCell DifferentiationCellular ReprogrammingDrug DiscoveryHigh-Throughput Screening AssaysHumansInduced Pluripotent Stem CellsRegenerative Medicine

Identifiers

PMID21371511
PMCPMC3109180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.