ArticleJournal of molecular biology2011
The architecture and conservation pattern of whole-cell control circuitry.
Article in Journal of molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- The effects of differential feeding on ileum development, digestive ability and health status of newborn calves.Frontiers in veterinary science · 2023Article
- Proteolysis dependent cell cycle regulation in Caulobacter crescentus.Cell division · 2022Review
- The type IV pilin PilA couples surface attachment and cell-cycle initiation inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Methodology for Ribosome Profiling of Key Stages of the Caulobacter crescentus Cell Cycle.Methods in enzymology · 2018Article
- Dynamic translation regulation in Caulobacter cell cycle control.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- CauloBrowser: A systems biology resource for Caulobacter crescentus.Nucleic acids research · 2016Article
- Essential Genome of the Metabolically Versatile Alphaproteobacterium Rhodopseudomonas palustris.Journal of bacteriology · 2015Article
- Synchronization of Caulobacter crescentus for investigation of the bacterial cell cycle.Journal of visualized experiments : JoVE · 2015Article
- The global regulatory architecture of transcription during the Caulobacter cell cycle.PLoS genetics · 2015Article
- Fifty years after the replicon hypothesis: cell-specific master regulators as new players in chromosome replication control.Journal of bacteriology · 2014Review
- The coding and noncoding architecture of the Caulobacter crescentus genome.PLoS genetics · 2014Article
- Dynamical modeling of the cell cycle and cell fate emergence in Caulobacter crescentus.PloS one · 2014Article
- Global methylation state at base-pair resolution of the Caulobacter genome throughout the cell cycle.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- De- and repolarization mechanism of flagellar morphogenesis during a bacterial cell cycle.Genes & development · 2013Article
- Life in a three-dimensional grid.The Journal of biological chemistry · 2012Article
- The Caulobacter crescentus ctrA P1 promoter is essential for the coordination of cell cycle events that prevent the overinitiation of DNA replication.Microbiology (Reading, England) · 2012Article
- Complete genome sequence of Caulobacter crescentus bacteriophage φCbK.Journal of virology · 2012Article
- The essential genome of a bacterium.Molecular systems biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The control circuitry that directs and paces Caulobacter cell cycle progression involves the entire cell operating as an integrated system. This control circuitry monitors the environment and the internal state of the cell, including the cell topology, as it orchestrates orderly activation of cell cycle subsystems and Caulobacter's asymmetric cell division. The proteins of the Caulobacter cell cycle control system and its internal organization are co-conserved across many alphaproteobacteria species, but there are great differences in the regulatory apparatus' functionality and peripheral connectivity to other cellular subsystems from species to species. This pattern is similar to that observed for the "kernels" of the regulatory networks that regulate development of metazoan body plans. The Caulobacter cell cycle control system has been exquisitely optimized as a total system for robust operation in the face of internal stochastic noise and environmental uncertainty. When sufficient details accumulate, as for Caulobacter cell cycle regulation, the system design has been found to be eminently rational and indeed consistent with good design practices for human-designed asynchronous control systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.