ArticleVirology journal2011
Occult HBV infection among Egyptian hepatocellular carcinoma patients.
Article in Virology journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Epidemiology of occult hepatitis B and C in Africa: A systematic review and meta-analysis.Journal of infection and public health · 2022Pooled it
- Chronic hepatitis B: Is it time for expanded antiviral treatment?World journal of virology · 2025Review
- Genetic diversity and occult hepatitis B infection in Africa: A comprehensive review.World journal of hepatology · 2024Article
- Prevalence of occult hepatitis B virus infection in Egypt: a systematic review with meta-analysis.The Journal of the Egyptian Public Health Association · 2023Review
- Occult Hepatitis B Virus Infection: An Update.Viruses · 2022Review
- High resolution HLA-DRB1 analysis and shared molecular amino acid signature of DRβ1 molecules in Occult hepatitis B infection.BMC immunology · 2022Article
- Thalassemia and hepatocellular carcinoma: links and risks.Journal of blood medicine · 2019Article
- Inhibition studies of HBV DNA polymerase using seed extracts of Pongamia pinnata.Bioinformation · 2019Article
- Effectiveness of PCR primers for the detection of occult hepatitis B virus infection in Mexican patients.PloS one · 2018Article
- Molecular characterization of occult hepatitis B virus infection in patients with end-stage liver disease in Colombia.PloS one · 2017Article
- Molecular mechanisms underlying HBsAg negativity in occult HBV infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Review
- Occult hepatitis B virus infection in Egypt.World journal of hepatology · 2015Review
- Occult hepatitis B virus infection in children born to HBsAg-positive mothers after neonatal passive-active immunoprophylaxis.Infection · 2015Article
- Hepatitis B virus Genotyping Among Patients With Cirrhosis.Jundishapur journal of microbiology · 2015Article
- Viral hepatitis markers in liver tissue in relation to serostatus in hepatocellular carcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Clinical significance of occult hepatitis B infection in progression of liver disease and carcinogenesis.Journal of Cancer · 2013Article
- Hepatitis C virus and other risk factors in hepatocellular carcinoma.Acta virologica · 2012Article
- Molecular mechanisms underlying occult hepatitis B virus infection.Clinical microbiology reviews · 2012Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOccult HBV infection accelerates the progression of liver fibrosis, cirrhosis, and finally leading to hepatocellular carcinoma (HCC). This study analyzed the occult HBV-genotypes in HCC patients.
methodsTo achieve our objective, matched serum and tissue samples were collected from 40 HCC patients. Three sets of primers were used for the HBV-DNA detection by nested-PCR, which cover the HBV-genome; Core, Surface and X genes. Genotyping system based on PCR using type-specific primers was applied on HBV-DNA positive samples.
resultsIntrahepatic occult HBV-DNA was detected in 62.5%, whereas; Serum occult HBV-DNA were detected in only 22.5% of HCC patients. In patients' positive for both anti-HBs and anti-HBc, 10% had occult HBV in serum. In serologically negative HCV patients, 63% had intrahepatic HBV-DNA, and 21% had HBV-DNA in serum samples. HBV-genotype D (32%) and B (24%) attributed predominantly to intrahepatic HBV infections in HCC patients, whereas HBV-genotype A (4%) and C (8%) infections were the least observed.
conclusionThis is the first study to show the genotypes of occult HBV infection in HCC Patients. We suggest that B or D may influence the outcome of HBV infection which may lead to the development of HCC.
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