ArticleParticle and fibre toxicology2011
Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells.
Article in Particle and fibre toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
102 citing papers in PubMed, 2 syntheses or guidelines pooled it, 391 citations in OpenAlex.
- Essential Oils in Experimental Models of Neuropsychiatric Disorders: A Systematic Review.Current neuropharmacology · 2021Pooled it
- Evaluation of the effect of time on the distribution of zinc oxide nanoparticles in tissues of rats and mice: a systematic review.IET nanobiotechnology · 2016Pooled it
- Effect of CuO on the Structural, Antimicrobial, and Redox Activity of TiOGels (Basel, Switzerland) · 2026Article
- Organ-specific apoptotic pathways induced by micro- and nanoplastics: a systematic review ofFrontiers in toxicology · 2026Review
- Biological Safety Analysis of Nanoparticles: Exploring Toxicity, Mechanisms, and Safety Factors for Pharmaceuticals.International journal of nanomedicine · 2026Review
- Three-dimensional cell sheet model improvesBioactive materials · 2025Article
- The effects of zinc oxide nanoparticles on the oxidative stress, caspase-3, cytokine and immunity in rats.Veterinarni medicina · 2025Article
- Comparative toxicity of zinc oxide nanoparticles and zinc salts in male mice: Hematological, biochemical, and histopathological impacts.Toxicology reports · 2025Article
- Novel Flavin Mononucleotide-Functionalized Cerium Fluoride Nanoparticles for Selective Enhanced X-Ray-Induced Photodynamic Therapy.Journal of functional biomaterials · 2024Article
- The Influence of Exogenous CdS Nanoparticles on the Growth and Carbon Assimilation Efficiency ofBiology · 2024Article
- Assessing the Toxicity of Metal- and Carbon-Based Nanomaterials In Vitro: Impact on Respiratory, Intestinal, Skin, and Immune Cell Lines.International journal of molecular sciences · 2024Article
- Biosynthesis and biocompatibility evaluation of zinc oxide nanoparticles prepared using Priestia megaterium bacteria.Scientific reports · 2024Article
- Electrospun Nanofiber Scaffolds Loaded with Metal-Based Nanoparticles for Wound Healing.Polymers · 2023Review
- Neuroprotective effects of quercetin on the cerebellum of zinc oxide nanoparticles (ZnoNps)-exposed rats.Tissue barriers · 2023Article
- Cadmium Sulfide Nanoparticles: Preparation, Characterization, and Biomedical Applications.Molecules (Basel, Switzerland) · 2023Review
- Role of Platinum Nanozymes in the Oxidative Stress Response ofAntioxidants (Basel, Switzerland) · 2023Article
- Metal-Based Nanoparticles and Their Relevant Consequences on Cytotoxicity Cascade and Induced Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Review
- Prediction of cytotoxicity of heavy metals adsorbed on nano-TiOBeilstein journal of nanotechnology · 2023Article
- Insights into nanoparticles-induced neurotoxicity and cope up strategies.Frontiers in neuroscience · 2023Review
- ZnO Nanoparticles from Different Precursors and Their Photocatalytic Potential for Biomedical Use.Nanomaterials (Basel, Switzerland) · 2022Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome manufactured nanoparticles are metal-based and have a wide variety of applications in electronic, engineering and medicine. Until now, many studies have described the potential toxicity of NPs on pulmonary target, while little attention has been paid to kidney which is considered to be a secondary target organ. The objective of this study, on human renal culture cells, was to assess the toxicity profile of metallic nanoparticles (TiO2, ZnO and CdS) usable in industrial production. Comparative studies were conducted, to identify whether particle properties impact cytotoxicity by altering the intracellular oxidative status.
resultsNanoparticles were first characterized by size, surface charge, dispersion and solubility. Cytotoxicity of NPs was then evaluated in IP15 (glomerular mesangial) and HK-2 (epithelial proximal) cell lines. ZnO and CdS NPs significantly increased the cell mortality, in a dose-dependent manner. Cytotoxic effects were correlated with the physicochemical properties of NPs tested and the cell type used. Analysis of reactive oxygen species and intracellular levels of reduced and oxidized glutathione revealed that particles induced stress according to their composition, size and solubility. Protein involved in oxidative stress such as NF-κb was activated with ZnO and CdS nanoparticles. Such effects were not observed with TiO2 nanoparticles.
conclusionOn glomerular and tubular human renal cells, ZnO and CdS nanoparticles exerted cytotoxic effects that were correlated with metal composition, particle scale and metal solubility. ROS production and oxidative stress induction clearly indicated their nephrotoxic potential.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.