ArticleMolecular microbiology2011
Two capsular polysaccharides enable Bacillus cereus G9241 to cause anthrax-like disease.
Article in Molecular microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
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- Comprehensive genomic analysis reveals virulence and antibiotic resistance genes in a multidrug-resistant Bacillus cereus isolated from hospital wastewater in Bangladesh.Scientific reports · 2025Article
- Decoding the anomalies: a genome-based analysis ofFrontiers in microbiology · 2025Article
- Toxin and capsule production by Bacillus cereus biovar anthracis influence pathogenicity in macrophages and animal models.PLoS neglected tropical diseases · 2024Article
- Investigating Anthrax-Associated Virulence Genes among Archival and ContemporaryPathogens (Basel, Switzerland) · 2024Article
- Hyaluronan synthases; mechanisms, myths, & mysteries of three types of unique bifunctional glycosyltransferases.Glycobiology · 2023Review
- Get to Know Your Neighbors: Characterization of CloseMicroorganisms · 2023Article
- Pathogenicity and Genomic Characterization of a Novel Genospecies,International journal of molecular sciences · 2023Article
- Retrospective Screening of Anthrax-like Disease Induced byPathogens (Basel, Switzerland) · 2023Article
- The influence of extrachromosomal elements in the anthrax "cross-over" strainFrontiers in microbiology · 2023Article
- Bacilli in the International Space Station.Microorganisms · 2022Article
- Contribution of TagA-Like Glycosyltransferases to the Assembly of the Secondary Cell Wall Polysaccharide in Bacillus anthracis.Journal of bacteriology · 2022Article
- Strains Associated with Two 2020 Welder Anthrax Cases in the United States Belong to Separate Lineages withinPathogens (Basel, Switzerland) · 2022Article
- Chemical Reporters for Bacterial Glycans: Development and Applications.Chemical reviews · 2022Review
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- Genomic Sequence Analysis of Methicillin- and Carbapenem-Resistant Bacteria Isolated from Raw Sewage.Microbiology spectrum · 2021Article
- Bacterial biopolymers: from pathogenesis to advanced materials.Nature reviews. Microbiology · 2020Review
- Article
- Characterization ofFrontiers in microbiology · 2020Article
- No Assembly Required: Using BTyper3 to Assess the Congruency of a Proposed Taxonomic Framework for theFrontiers in microbiology · 2020Article
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4 authors.
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Abstract
Bacillus cereus G9241 causes an anthrax-like respiratory illness in humans; however, the molecular mechanisms of disease pathogenesis are not known. Genome sequencing identified two putative virulence plasmids proposed to provide for anthrax toxin (pBCXO1) and/or capsule expression (pBC218). We report here that B. cereus G9241 causes anthrax-like disease in immune-competent mice, which is dependent on each of the two virulence plasmids. pBCXO1 encodes pagA1, the homologue of anthrax protective antigen, as well as hasACB, providing for hyaluronic acid capsule formation, two traits that each contribute to disease pathogenesis. pBC218 harbours bpsX-H, B. cereus exo-polysaccharide, which produce a second capsule. During infection, B. cereus G9241 elaborates both hasACB and bpsX-H capsules, which together are essential for the establishment of anthrax-like disease and the resistance of bacilli to phagocytosis. A single nucleotide deletion causes premature termination of hasA translation in Bacillus anthracis, which is known to escape phagocytic killing by its pXO2 encoded poly-d-γ-glutamic acid (PDGA) capsule. Thus, multiple different gene clusters endow pathogenic bacilli with capsular material, provide for escape from innate host immune responses and aid in establishing the pathogenesis of anthrax-like disease.
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