ArticleJournal of the American Chemical Society2011
Manganese(III) complexes of bis(hydroxyphenyl)dipyrromethenes are potent orally active peroxynitrite scavengers.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Suppression of Paclitaxel-Induced Neuropathy and Ovarian Tumor Growth by Mn Porphyrin, MnTnBuOE-2-PyPOxidative medicine and cellular longevity · 2025Article
- Synthetic Exploration of Bis(phenolate) Aza-BODIPYs and Heavier Group 13 Chelates.Molecules (Basel, Switzerland) · 2022Article
- Ligand-Mediated Spin-State Changes in a Cobalt-Dipyrrin-Bisphenol Complex.Inorganic chemistry · 2020Article
- Gold dipyrrin-bisphenolates: a combined experimental and DFT study of metal-ligand interactions.RSC advances · 2019Article
- Inhibition of protein nitration prevents cisplatin-induced inactivation of STAT3 and promotes anti-apoptotic signaling in organ of Corti cells.Experimental cell research · 2019Article
- Nanoscale metal-organic frameworks coated with poly(vinyl alcohol) for ratiometric peroxynitrite sensing through FRET.Chemical science · 2017Article
- Synthesis of Cycloprodigiosin Identifies the Natural Isolate as a Scalemic Mixture.Organic letters · 2015Article
- SR-135, a peroxynitrite decomposing catalyst, enhances β-cell function and survival in B6D2F1 mice fed a high fat diet.Archives of biochemistry and biophysics · 2015Article
- Metal complexes as potential modulators of inflammatory and autoimmune responses.Chemical science · 2015Article
- Mitotoxicity in distal symmetrical sensory peripheral neuropathies.Nature reviews. Neurology · 2014Review
- SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.Antioxidants & redox signaling · 2014Review
- Article
- Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.Free radical biology & medicine · 2013Article
- Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013Review
- Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Anti-superoxide and anti-peroxynitrite strategies in pain suppression.Biochimica et biophysica acta · 2012Article
- Cisplatin-induced apoptosis in auditory, renal, and neuronal cells is associated with nitration and downregulation of LMO4.Cell death discoveryArticle
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Authors and funding
7 authors.
Funding
Abstract
We report a new series of biscyclohexano-fused Mn(III) complexes of bis(hydroxyphenyl)dipyrromethenes, 4a-c, as potent and orally active peroxynitrite scavengers. Complexes 4a-c are shown to reduce peroxynitrite through a two-electron mechanism, thereby forming the corresponding Mn(V)O species, which were characterized by UV, NMR, and LC-MS methods. Mn(III) complex 4b and its strained BODIPY analogue 9b were analyzed by X-ray crystallography. Finally, complex 4a is shown to be an orally active and potent analgesic in a model carrageenan-induced hyperalgesia known to be driven by the overproduction of peroxynitrite.
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