ArticleEnvironmental health perspectives2011
A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphoma.
Article in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Trichloroethylene and cancer: systematic and quantitative review of epidemiologic evidence for identifying hazards.International journal of environmental research and public health · 2011Pooled it
- Childhood cancer risk in offspring of mothers occupationally exposed to hydrocarbon solvents.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026Article
- Declining incidence and improving survival of ocular and orbital lymphomas in the US between 1995 and 2018.Scientific reports · 2024Article
- Review
- Modeling historic environmental pollutant exposures and non-Hodgkin lymphoma risk.Environmental research · 2023Article
- Why We Will Continue to Lose Our Battle with Cancers If We Do Not Stop Their Triggers from Environmental Pollution.International journal of environmental research and public health · 2021Review
- International Inventory of Occupational Exposure Information: OMEGA-NET.Annals of work exposures and health · 2020Article
- Estimation of Source-Specific Occupational Benzene Exposure in a Population-Based Case-Control Study of Non-Hodgkin Lymphoma.Annals of work exposures and health · 2019Review
- What to Do When Accumulated Exposure Affects Health but Only Its Duration Was Measured? A Case of Linear Regression.International journal of environmental research and public health · 2019Article
- Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin's lymphoma.Occupational and environmental medicine · 2018Article
- High-resolution metabolomics of occupational exposure to trichloroethylene.International journal of epidemiology · 2016Article
- Comparison of hematological alterations and markers of B-cell activation in workers exposed to benzene, formaldehyde and trichloroethylene.Carcinogenesis · 2016Article
- Residential cancer cluster investigation nearby a Superfund Study Area with trichloroethylene contamination.Cancer causes & control : CCC · 2016Article
- Validity of expert assigned retrospective estimates of occupational polychlorinated biphenyl exposure.The Annals of occupational hygiene · 2015Article
- Exposure Reconstruction and Risk Analysis for Six Semiconductor Workers With Lymphohematopoietic Cancers.Journal of occupational and environmental medicine · 2015Article
- Using hierarchical cluster models to systematically identify groups of jobs with similar occupational questionnaire response patterns to assist rule-based expert exposure assessment in population-based studies.The Annals of occupational hygiene · 2015Article
- Identifying gender differences in reported occupational information from three US population-based case-control studies.Occupational and environmental medicine · 2014Article
- Occupational health risks among trichloroethylene-exposed workers in a clock manufacturing factory.Global journal of health science · 2014Article
- Medical history, lifestyle, family history, and occupational risk factors for peripheral T-cell lymphomas: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.Journal of the National Cancer Institute. Monographs · 2014Article
- Environmental determinants of polychlorinated biphenyl concentrations in residential carpet dust.Environmental science & technology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundPrevious epidemiologic findings suggest an association between exposure to trichloroethylene (TCE), a chlorinated solvent primarily used for vapor degreasing of metal parts, and non-Hodgkin lymphoma (NHL).
objectivesWe investigated the association between occupational TCE exposure and NHL within a population-based case-control study using detailed exposure assessment methods.
methodsCases (n = 1,189; 76% participation rate) and controls (n = 982; 52% participation rate) provided information on their occupational histories and, for selected occupations, on possible workplace exposure to TCE using job-specific interview modules. An industrial hygienist assessed potential TCE exposure based on this information and a review of the TCE industrial hygiene literature. We computed odds ratios (ORs) and 95% confidence intervals (CIs) relating NHL and different metrics of estimated TCE exposure, categorized using tertiles among exposed controls, with unexposed subjects as the reference group.
resultsWe observed associations with NHL for the highest tertiles of estimated average weekly exposure (23 exposed cases; OR = 2.5; 95% CI, 1.1–6.1) and cumulative exposure (24 exposed cases; OR = 2.3; 95% CI, 1.0-5.0) to TCE. Tests for trend with these metrics surpassed or approached statistical significance (p-value for trend = 0.02 and 0.08, respectively); however, we did not observe dose–response relationships across the exposure levels. Overall, neither duration nor intensity of exposure was associated with NHL, although we observed an association with the lowest tertile of exposure duration (OR = 2.1; 95% CI, 1.0-4.7).
conclusionsOur findings offer additional support for an association between high levels of exposure to TCE and increased risk of NHL. However, we cannot rule out the possibility of confounding from other chlorinated solvents used for vapor degreasing and note that our exposure assessment methods have not been validated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.